Terutroban

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Terutroban
File:Terutroban structure.svg
Systematic (IUPAC) name
Sodium 3-((6R)-6-{[(4-chlorophenyl)sulfonyl]amido}-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoate
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Investigational
Pharmacokinetic data
Biological half-life 6-10 hours
Identifiers
ATC code none
PubChem CID 23674098
Chemical data
Formula C20H21ClNNaO4S
Molar mass 429.892 g/mol[[Script error: No such module "String".]]
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Terutroban is an antiplatelet agent developed by Servier Laboratories. As of 2008, it is tested for the secondary prevention of acute thrombotic complications in the Phase III clinical trial PERFORM.

Method of action

Terutroban is a selective antagonist of the thromboxane receptor. It blocks thromboxane induced platelet aggregation and vasoconstriction.

References

  • H. Spreitzer (January 29, 2007). "Neue Wirkstoffe - Terutroban". Österreichische Apothekerzeitung (in German) (3/2007): 116. 
  • Sorbera, LA, Serradell, N, Bolos, J, Bayes, M (2006). "Terutroban sodium". Drugs of the Future. 31 (10): 867–873. doi:10.1358/dof.2006.031.10.1038241. 


pt:Terutroban