Brentuximab vedotin
From Self-sufficiency
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Template:Infobox drug/mab source |
| Target | CD30 |
| Identifiers | |
| CAS Number | 914088-09-8 |
| ATC code | none |
| Chemical data | |
| Formula | C6476H9930N1690O2030S40 (C68H105N11O15)3–5 |
Brentuximab vedotin (SGN-35) is a drug being investigated for hematological malignancies like anaplastic large cell lymphoma[1] and Hodgkin's lymphoma.[2][3][4]
A molecule of the drug consists of the chimeric monoclonal antibody brentuximab and three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). MMAE is responsible for the anti-tumour activity.[5][6]
References
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- ↑ ClinicalTrials.gov NCT00866047 A Phase 2 Open Label Trial of SGN-35 for Systemic Anaplastic Large Cell Lymphoma
- ↑ ClinicalTrials.gov NCT00848926 A Pivotal Open-Label Trial of SGN-35 for Hodgkin Lymphoma
- ↑ ClinicalTrials.gov NCT00649584 A Phase I Dose Escalation Study of SGN-35 Alone and in Combination With Gemcitabine for CD30-Positive Malignancies
- ↑ ClinicalTrials.gov NCT00430846 Phase I Open-Label Dose Finding Study of SGN-35 for CD30 Positive Hematologic Malignancies
- ↑ Seattle Genetics: Brentuximab vedotin (SGN-35)
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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