Fasudil

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Fasudil
File:Fasudil.png
Systematic (IUPAC) name
5-(1,4-diazepane-1-sulfonyl)isoquinoline
Pharmacokinetic data
Bioavailability well absorbed
Metabolism metabolized quickly to hydroxyfasudil
Biological half-life 0.76 hours. Active metabolite (hydroxyfasudil) 4.66 hours.
Identifiers
CAS Number 103745-39-7
ATC code C04AX32 (WHO)
PubChem CID 3547
Chemical data
Formula C14H17N3O2S
Molar mass 291.36 g/mol[[Script error: No such module "String".]]
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Fasudil Hydrochloride (INN) is a potent Rho-kinase inhibitor and vasodilator[1]. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage,[2] as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension. [3] It was demonstrated in February of 2009 that Fasudil could also be used to enhance memory and improve the prognosis of Alzheimers patients.[4]

References

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Peripheral vasodilators (C04)
2-amino-1-phenylethanol derivatives
Imidazoline derivatives/
Alpha blockers
Niacin and derivatives
Purine derivatives
Ergot alkaloids
Other peripheral vasodilators


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  1. ↑ . Science Daily http://www.sciencedaily.com/releases/2009/02/090202102932.htm.  Missing or empty |title= (help)
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ Doggrell SA (2005). "Rho-kinase inhibitors show promise in pulmonary hypertension". Expert Opin Investig Drugs. 14 (9): 1157–1159. doi:10.1517/13543784.14.9.1157. PMID 16144499. 
  4. ↑ Huentelman, Matthew J.; Stephan, DA; Talboom, J; Corneveaux, JJ; Reiman, DM; Gerber, JD; Barnes, CA; Alexander, GE; Reiman, EM (2009). "Peripheral delivery of a ROCK inhibitor improves learning and working memory". Behavioral Neuroscience. 123 (1): 218. doi:10.1037/a0014260. PMC 2701389 Freely accessible. PMID 19170447. 
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