Fenbendazole
| File:Fenbendazole.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
methyl N-(6-phenylsulfanyl-1H-benzoimidazol- 2-yl)carbamate | |
| Identifiers | |
| CAS Number | 43210-67-9 |
| ATC code | P02CA06 (WHO) QP52AC13 |
| PubChem | CID 3334 |
| Chemical data | |
| Formula | C15H13N3O2S |
| Molar mass | 299.349 g/mol[[Script error: No such module "String".]] |
Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.[1]
Toxicity
Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves), and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppresion, intestinal crypt cell necrosis and distal villi sloughing.[citation needed] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.[citation needed]
Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally.[1]
References
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