Janeway lesion

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Janeway lesion
Classification and external resources
ICD-10 A41.8 (ILDS A41.820)

Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are pathognomonic of infective endocarditis.[1] Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[2] Janeway lesions are distal, flat, ecchymotic, and painless.

Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness.[3]


They are named after Edward G. Janeway (1841–1911), an American professor of medicine with interests in cardiology and infectious disease.[4]

See also


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Supporting images


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  2. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.
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  4. Janeway C. (1998). "Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response". J. Immunol. 161 (2): 539–44. PMID 9670925.