Occupational asthma

Occupational asthma is an occupational condition defined as:

"a disease characterized by variable airflow limitation and/or airway hyper-responsiveness due to causes and conditions attributable to a particular occupational environment and not stimuli encountered outside the workplace".

Asthma is defined as a respiratory disease caused by narrowing of the air passages. It is synonymous with difficulty in breathing, tightness of chest, nasal irritation, coughing and wheezing. The first person to use it in reference to a medical condition was Hippocrates, and he believed that tailors, anglers and metalworkers were more likely to be affected by the disease. Although much research has been done since, the inflammatory component of asthma was recognized only in the 1960s.

Today, asthma affects as much as 15% of the Canadian population (and this is true of other developed countries too) and has increased fourfold in the last 20 years. Various reasons can be identified for this increase - Of course better diagnosis and facilities along with a greater awareness regarding the disease have played a major role. But, one cannot deny the part of increased environmental pollution. Researchers have been working on the relation between the environment and human health since long and the air we breathe is the primary cause for lung diseases like asthma, rhinitis, COPDs, etc. that affect us today.

Approximately 10 to 15% of the adults affected by the disease report an aggravation of their symptoms while at work and an improvement when away, which implies that they may be suffering from Occupational Asthma. Thus, when an individual’s Asthma is caused, not aggravated, by workplace materials, it is defined as Occupational Asthma. In the USA, OA is considered the most common occupational lung disease. At present, over 400 workplace substances have been identified as having asthmagenic or allergenic properties. Their existence and magnitude vary from region to region and the type of industry and can be as varied as wood dust (cedar, ebony, etc.), persulfates (Hairsprays), zinc or even seafood like prawns. For example, in France the industries most affected in order of importance are Bakeries and cake-shops, automobile industry and hairdressers, whereas in Canada the principal cause is wood dust, followed by isocyanates.

Hypersensitivity pneumonitis is a related condition, with many occupational examples (e.g. "Farmer's Lung", "Malt Worker's Lung" and "Humidifier Lung" etc.). However, although overlapping in many cases, hypersensitivity pneumonitis may be distinguished from occupational asthma in that it isn't restricted to only occupational exposure, and involves type III hypersensitivity and type IV hypersensitivity rather than type I hypersensitivity of asthma. Unlike asthma, hypersensitivity pneumonitis targets lung alveoli rather than bronchi.

Signs and symptoms

Less than five years of exposure to an occupational agent can be enough for the appearance of the first OA symptoms. This depends on whether the reason for the OA to occur was exposure to the causative agent over a period of time (with a latency period) or a single exposure to an irritant but at a very high concentration (without latency period). Both eventually result in OA. Coughing, wheezing, nasal irritation, difficulty in breathing, tightness of chest are the most common symptoms and can be recognized more easily by asking oneself the following questions:

1. Are any of the above symptoms recurrent/chronic?
2. Are they present at work?
3. Do they worsen towards the end of the work day and/or end of the week?
4. Does the employee/worker feel an improvement in his condition when away from work, on vacation or on weekends?

If these symptoms persist, the person is most likely suffering from OA. However, one must be aware that this could also be because the person is already suffering from asthma and his condition was simply aggravated by workplace irritants (Work-aggravated asthma). In this case, although he will suffer similar consequences as someone who is suffering from OA (loss of work, medical expenses, etc.), his disease cannot be considered as having an occupational origin.

Diagnosis

Like for any other disease correct diagnosis is important. According to Dr. Susan Tarlo:

“It is important to recognize, since if due to a workplace sensitizer and, if undetected and if the patient continues to work with even small exposure to the relevant sensitizing agent, the prognosis is worse”. She also concluded that, “the chance of eventual improvement in Asthma severity after stopping exposure decreases with the duration of exposure after the onset of the symptoms. The best chance of asthma clearing or significantly improving is associated with early diagnosis and early removal from ongoing exposure”.

However, the biggest challenge is the first step – Family doctors and patients alike do not have sufficient knowledge about Occupational Asthma - only 15% of the asthmatic patients are asked by their doctor if their symptoms are related to work. And often, patients do not mention this possibility due to the fear of losing their jobs or simply because they are not aware of the association between their work and asthma. What they do not realize is that if they continue working under such circumstances, not only are they sure to lose their job in the long run but their asthma will also reach an irreversible stage. Clearly, an incorrect diagnosis will have considerable medical, social and financial consequences.

Diagnosis of OA is a process and has to be done over a period of time. First, the patient’s occupational and clinical history is taken and his symptoms are charted (Charting is usually done at the end of a typical work week and within 24 hours of the occurrence of symptoms in order to get objective information). Once this has been established, the following diagnostic methods are used:

Non-specific bronchial hyperreactivity

A non-specific bronchial hyperreactivity test involves testing with methacoline, after which the Forced Expiratory Volume in 1 second (FEV₁) of the patient is measured. This test is often used for measuring the intensity of a person's asthma and to confirm that the person needs to be treated for asthma. Other non specific tests could even require the patient to run in open air or on a treadmill for a few minutes at a continuous pace. In this case, the individual’s Peak Expiratory Flow Rate (PEFR) is measured. (The peak expiratory flow rate measures how fast a person can exhale) .

Skin prick tests

Although called skin prick test, it does not involve drawing blood, in fact, the skin is not even scratched. It is usually performed on the inner aspect of the forearm where grid is marked (using a simple marker) and a drop of the allergen that is to be tested is placed on the arm at the end of each line. All the allergens that need to be tested can be similarly placed on the grid. Once this has been done, the skin is pricked through the drop using a lancet. Reactions, if any, occur within 10 to 15 minutes and these results can then be analyzed.

IgE-specific tests

Immunoglobulin E is an antibody found in our blood and is effective against toxins. Since it can also trigger allergic reactions to specific allergens like pollen, the IgE test is performed to evaluate whether the subject is allergic to these substances.

Spirometric tests

Conventionally, a spirometer can be defined as a device used to measure timed expired and inspired volumes. These volumes then enable us to measure how quickly the lungs can be emptied and filled and whether it is effective. These measurements need to be stated at body temperature, and the pressure will have to be saturated with water vapor to get the correct values. This is because, if the spirometer is dry the recorded volume of air displaced is lower than that actually displaced by the lungs.

Peak Expiratory Flow at work

This test uses the PEFR method. The only difference is that it measures the functioning of the patient's airways at his place of work and not necessarily in a controlled environment. The patient breathes into a Peak Expiratory Flow monitor (a hand-held device that has a mouth piece at one end and a scale with an indicator on the other).

Specific inhalation challenge

• Realistic method

“The Realistic Method” is a whole body sealed chamber where the patient is exposed to articles that are present in their workplace. This method has the advantage of being able to assess, albeit highly subjectively, ocular and nasal symptoms as well as a reduction in FEV₁.

• Closed-circuit method

This test requires the patient to breathe aerosols of the suspected ‘asthmagens’ through an oro-facial mask. These ‘asthmagens’ are aerosolized using closed circuit chambers, and the quantities and concentrations administered being minute and extremely stable minimize the risk of exaggerated responses.

Of the above methods of doing a diagnosis, procedures such as monitoring of spirometry or peak expiratory flow at work and Specific Inhalation Challenges (SIC) have been proved as the most objective and reliable methods.

Prevention and treatment

According to the Canadian Centre for Occupational Health and Safety (CCOHS) better education of workers, management, unions and medical professionals is the key to the prevention of OA. This will enable them to identify the risk factors and put in place preventive measures like masks or exposure limits, etc.

Recovery is directly dependent on the duration and level of exposure to the causative agent. Depending on the severity of the case, the condition of the patient can improve dramatically during the first year after removal from exposure.

Three basic types of procedures are used for treating the affected workers:

1) Reducing exposure

This method is most effective for those affected by irritant-induced OA. Thus, by reducing their exposure duration and level to the causative agent, the probability of suffering another reaction is lowered. But exposure can be reduced in other ways like making use of face masks or providing better ventilation. Now, more and more di-isocyanate free spray paints are available. Similarly, most hospitals and healthcare companies have exchanged latex gloves for other materials. Thus, reducing exposure to known asthmagens can also be used as a preventive measure.

2) Removal from exposure

Persons affected by OA that occurred after a latency period, whether a few months or years, must be immediately removed from exposure to the causative agent. This is their only chance of recovery. However, this entails severe socio-economic consequences for the worker as well as the employer due to loss of job, unemployment, compensation issues, quasi-permanent medical expenditures, hiring and re-training of new personnel, etc. Also, according to recent research the probability that those who suffer from OA remain unemployed longer than those who suffer from non-occupational asthma is higher. One solution to this problem is relocating the employee in the same company away from the causative agents.

3) Medical and pharmacological treatment

Anyone diagnosed with Asthma will have to undergo medical treatment. This is complementary to either removing or reducing the patient’s exposure to the causal agents. Two types of medication can be used:

• Relievers or bronchodilators
Main article: Bronchodilator

Short-acting beta-agonists like salbutamol or terbutaline or long-acting beta-agonists like salmeterol and formoterol or anticholinergic, etc. dilate airways which relieve the symptoms thus reducing the severity of the reaction. Some patients also use it just before work to avoid a drop in the FEV₁.

• Preventers

Anti-inflammatory agents like corticosteroids, LKTRA or mast cell stabilizers can be used depending on the severity of the case.

History

In 1700, Bernardino Ramazzini, Doctor of Philosophy and Medicine from Parma, Italy published the book “De Morbis Artificum Diatriba” (A Treatise on the Diseases of Workers). Although researchers like Olaus Magus had done work on diseases due to occupational causes as early as 1555, this was the first comprehensive work on work-related diseases. This volume described in detail the diseases of workers in 52 different occupations. Thus, it was the basis for the emergence of occupational medicine and even today, it is an important reference. Due to his important contribution to this field, Dr. Ramazzini is considered the father of occupational medicine.

Similarly, for his contribution to research on asthma in the workplace, Dr Jack Pepys is considered as the Father of Occupational Asthma. His work on the role of Aspergillus species in pulmonary diseases as also on the cause of farmer’s lung have heavily influenced the emergence of OA as an occupational disease. And, thanks to his work on Specific Inhalation Challenge, the compensatible aspect of the disease was recognized.

Society and culture

Compensation

As mentioned earlier, when a person is diagnosed as having occupational asthma, it results in serious socio-economic consequences not only for the workers but also for the employer and the healthcare system. The employee has to be taken off job immediately to prevent any further damage to his health. And, the probability of being re-employed is lower for those suffering from OA as compared to those suffering from normal asthma. The employer not only pays compensation to the employee, but will also have to spend a considerable amount of time and energy and funds for hiring and training new personnel.

Occupations at risk

The following tables show occupations that are known to be at risk for occupational asthma, and main substances involved.

Yet, the riskiest occupations for asthma are: adhesive handlers (e.g. acrylate), animal handlers and veterinarians (animal proteins), bakers and millers (cereal grains), carpet makers (gums), electronics workers (soldering resin), forest workers, carpenters and cabinetmakers (wood dust), hairdressers (e.g. persulfate), health care workers (latex and chemicals such as glutaraldehyde), janitors and cleaning staff (e.g. chloramine-T), pharmaceutical workers (drugs, enzymes), seafood processors, shellac handlers (e.g. amines), solderers and refiners (metals), spray painters, insulation installers, plastics and foam industry workers (e.g. diisocyanates), textile workers (dyes) and users of plastics and epoxy resins (e.g. anhydrides)

Grains, flours, plants and gums
Occupation	Agent
Bakers, millers	Wheat
Chemists, coffee bean baggers and handlers, gardeners, millers, oil industry workers, farmers	Castor beans
Cigarette factory workers	Tobacco dust
Drug manufacturers, mold makers in sweet factories, printers	Gum acacia
Farmers, grain handlers	Grain dust
Gum manufacturers, sweet makers	Gum tragacanth
Strawberry growers	Strawberry pollen
Tea sifters and packers	Tea dust
Tobacco farmers	Tobacco leaf
Woollen industry workers	Wool

Animals, insects and fungi
Occupation	Agent
Bird fanciers	Avian proteins
Cosmetic manufacturers	Carmine
Entomologists	Moths, butterflies
Feather pluckers	Feathers
Field contact workers	Crickets
Fish bait breeders	Bee moths
Flour mill workers, bakers, farm workers, grain handlers	Grain storage mites, alternaria, aspergillus
Laboratory workers	Locusts, cockroaches, grain weevils, rats, mice, guinea pigs, rabbits
Mushroom cultivators	Mushroom spores
Oyster farmers	Sea pineapples (Hoya)
Pea sorters	Mexican bean weevils
Pigeon breeders	Pigeons
Poultry workers	Chickens
Prawn processors	Prawns
Silkworm sericulturers	Silkworms
Zoological museum curators	Beetles

Chemicals/Materials
Occupation	Agent
Aircraft fitters	Triethyltetramine
Aluminum cable solderers	Aminoethylethanolamine
Aluminum pot room workers	Fluorine
Autobody workers	Acrylates (resins, glues, sealants, adhesives)
Brewery workers	Chloramine-T
Chemical plant workers, pulp mill workers	Chlorine
Dye weighers	Levafix brilliant yellow, drimarene brilliant yellow and blue, cibachrome brilliant scarlet
Electronics workers	Colophony
Epoxy resin manufacturers	Tetrachlorophthalic anhydride
Foundry mold makers	Furan-based resin binder systems
Fur dyers	Para-phenylenediamine
Hairdressers	Persulphate salts
Health care workers	Glutaraldehyde, latex
Laboratory workers, nurses, phenolic resin molders	Formaldehyde
Meat wrappers	Polyvinyl chloride vapour
Paint manufacturers, plastic molders, tool setters	Phthalic anhydride
Paint sprayers	Dimethylethanolamine
Photographic workers, shellac manufacturers	Ethylenediamine
Refrigeration industry workers	CFCs
Solderers	Polyether alcohol, polypropylene glycol

Isocyanates and metals
Occupation	Agent
Boat builders, foam manufacturers, office workers, plastics factory workers, refrigerator manufacturers, TDI manufacturers/users, printers, laminators, tinners, toy makers	TDI
Boiler cleaners, gas turbine cleaners	Vanadium
Car sprayers	Hexamethylene diisocyanate
Cement workers	Potassium dichromate
Chrome platers, chrome polishers	Sodium bichromate, chromic acid, potassium chromate
Nickel platers	Nickel sulphate
Platinum chemists	Chloroplatinic acid
Platinum refiners	Platinum salts
Polyurethane foam manufacturers, printers, laminators	Diphenylmethane diisocyanate
Rubber workers	Naphthalene diisocyanate
Tungsten carbide grinders	Cobalt
Welders	Stainless steel fumes

Drugs and enzymes
Occupation	Agent
Ampicillin manufacturers	Phenylglycine acid chloride
Detergent manufacturers	Bacillus subtilis
Enzyme manufacturers	Fungal alpha-amylase
Food technologists, laboratory workers	Papain
Pharmacists	Gentian powder, flaviastase
Pharmaceutical workers	Methyldopa, salbutamol, dichloramine, piperazine dihydrochloride, spiramycin, penicillins, sulphathiazole, sulphonechloramides, chloramine-T, phosdrin, pancreatic extracts
Poultry workers	Amprolium hydrochloride
Process workers, plastic polymer production workers	Trypsin, bromelin

Woods
Occupation	Agent
Carpenters, timber millers, woodworkers	Western red cedar, cedar of Lebanon, iroko, California redwood, ramin, African zebrawood
Sawmill workers, pattern makers	Mansonia, oak, mahogany, abiruana
Wood finishers	Cocabolla
Wood machinists	Kejaat

See also

• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Specific inhalation challenge

External links

• Asthma in the Workplace - For any questions on occupational asthma
• Canadian Lung Association - For all you need to know about Lung diseases, including occupational respiratory diseases
• SCL Medtech - For any questions on workplace asthma diagnosis, especially Specific Inhalation Challenge
• http://www.asthma.org.uk/all_about_asthma/asthma_at_work/occupational.html
• Occupational Asthma (UK) - Created by some of the most important people in the field, in UK. For any questions/ help on Workplace asthma
• National Institute for Occupational Safety and Health - Asthma and Allergies Page

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