Odanacatib

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Odanacatib
File:Odanacatib.png
Systematic (IUPAC) name
N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide
Clinical data
Routes of
administration
oral
Identifiers
CAS Number 603139-19-1
ATC code none
PubChem CID 10152654
Synonyms (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-(methanesulfonyl)-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanamide
Chemical data
Formula C25H27F4N3O3S
Molar mass 525.56 g/mol[[Script error: No such module "String".]]
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Odanacatib (pINN; codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis[1]. It is an inhibitor of cathepsin K,[2] an enzyme involved in bone resorption.

It is being developed by Merck & Co. As of November 2009, Merck is conducting phase III clinical trials.

References

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  1. Le Gall, C. L.; Bonnelye, E.; Clézardin, P. (2008). "Cathepsin K inhibitors as treatment of bone metastasis". Current Opinion in Supportive and Palliative Care. 2 (3): 218. doi:10.1097/SPC.0b013e32830baea9. PMID 18685424.  edit
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