Opiorphin
From Self-sufficiency
| Opiorphin[1] | |
|---|---|
| File:Opiorphin.png | |
| (2S,5S,8S,11S,14S)-14,17-diamino-8-benzyl-2,11-bis(3-guanidinopropyl)-5-(hydroxymethyl)-4,7,10,13,17-pentaoxo-3,6,9,12-tetraazaheptadecan-1-oic acid | |
| Other names Gln-Arg-Phe-Ser-Arg; L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 864084-88-8 
|
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C29H48N12O8 |
| Molar mass | 692.77 g mol−1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakdown of natural pain-killing opioids in the spine, called enkephalins. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg.[2][3][4][5][6][7][8][9]
Opiorphin pentapetide originates from the N-terminal region of the protein PROL1 (proline rich, lacrimal 1).[2] Opiorphin inhibits two proteases: neutral ecto-endopeptidase (MME) and ecto-aminopeptidase N (ANPEP).[2]
See also
References
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<references />, or <references group="..." />- ↑ Opiorphin at Sigma-Aldrich
- ↑ 2.0 2.1 2.2 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Andy Coghlan (November 13, 2006). "Natural-born painkiller found in human saliva". New Scientist.
- ↑ "Natural chemical 'beats morphine'". BBC News. November 14, 2006.
- ↑ Mary Beckman (November 13, 2006). "Prolonging Painkillers". ScienceNOW.
- ↑ Stanovic S, Boranic M, Petrovecki M, Batinic D, Skodlar J, Nemet D, Labar B. Haematologia. 2000; 30(1):1-10.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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