Racecadotril

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Racecadotril
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Systematic (IUPAC) name
(RS)-benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 81110-73-8
ATC code A07XA04 (WHO)
PubChem CID 107751
Synonyms benzyl 2-[3-(acetylthio)-2-benzylpropanamido]acetate
Chemical data
Formula C21H23NO4S
Molar mass 385.47662 g/mol[[Script error: No such module "String".]]
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Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.[1] Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine.[2] It is available in France (where it was first introduced in 1993 and is widely used) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan.

A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.[3]

Thiorphan is the active metabolite of racecadotril.[4]

See also

References

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Intestinal anti-infectives
Intestinal adsorbents
Antipropulsives (opioids)
Opium (Laudanum) · Codeine · Morphine (Paregoric)

crosses BBB: Diphenoxylate · Difenoxin

does not cross BBB: Loperamide
Intestinal anti-inflammatory agents
Antidiarrheal micro-organisms
Other antidiarrheals
Albumin tannate · Ceratonia · Octreotide · Racecadotril


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  1. ↑ Matheson AJ, Noble S. Racecadotril. Drugs. 2000 Apr;59(4):829-35. PMID 10804038
  2. ↑ (2001) "Racecadotril: an Antidiarrhoeal Suitable for Use in Infants and Young Children". Drug Ther Perspect 17 (8): 1–5. Free full text with registration at Medscape
  3. ↑ Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, Gutierrez M (2000). "Racecadotril in the treatment of acute watery diarrhea in children". N. Engl. J. Med. 343 (7): 463–7. doi:10.1056/NEJM200008173430703. PMID 10944563. 
  4. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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