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...be subtherapeutic. Nitrofurantoin should not be used in patients with a [[creatinine clearance]] of 60 mL/min or less. However a retrospective chart review may

Trimethoprim can also reduce clearance of creatinine at renal tubules.

...this potential, blood levels of the drug and markers of kidney function ([[creatinine]]) may be monitored.

* Renal function: Increased [[Blood urea nitrogen|BUN]] and serum [[creatinine]] have been noted. [[Crystalluria]] (formation of crystals and excretion in

...closporine]] has also been associated with transient elevations in serum [[creatinine]]. Renal tubular transport of [[methotrexate]] may be inhibited by concomit

...ncrease the risk of [[lactic acidosis]], including [[kidney]] disorders ([[creatinine]] levels over 150 μmol/l,<ref name="Jones2003">{{vcite journal |author=Jon

...cal significance in mediating drug effects. Renal impairment [particularly creatinine clearance < 20 ml/min (< 1.2 L/h)] results in significant accumulation of e

...w to Use"] Health Digest, Retrieved 27 May 2010.</ref> For patients whose creatinine clearance is less than 10 mL/min, the dosage should start at 2.5 mg/day, ad

...cupational exposure are 500 μg/g creatinine for muconic acid and 25 μg/g creatinine for phenylmercapturic acid in an end-of-shift urine specimen.<ref>{{cite jo

* Severe renal insufficiency (creatinine clearance <30 ml/min)