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Systematic (IUPAC) name
Clinical data
  • AU: D
  • US: C (Risk not ruled out)
Routes of
Intramuscular, intravenous
Legal status
Legal status
Pharmacokinetic data
Protein binding 0-11%
Biological half-life 2-3 hours
Excretion Renal
CAS Number 37517-28-5
ATC code D06AX12 (WHO) J01GB06, S01AA21
PubChem CID 37768
DrugBank APRD00550
ChemSpider 34635
Chemical data
Formula C22H43N5O13
Molar mass 585.603 g/mol[[Script error: No such module "String".]]
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Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.


Amikacin may be administered once or twice a day but must be given by the intravenous or intramuscular route. There is no oral form available. Dosage must be adjusted in people with kidney failure.


Amikacin is most often used for treating severe, hospital-acquired infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter.

Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever.


Amikacin has high resistance against bacterial inactivation. It resists attacks by most bacterial inactivating enzymes, this is accomplished by the L-hydroxyaminobuteroyl amide (L-HABA) moiety attached to N-3 which inhibits acetylation, phosphorylation and adenylation in the distant amino sugar ring (C-2,C-3,C-4). To prevent the development of bacterial resistance to this extremely powerful antibiotic, its use is tightly regulated.

Side effects

Side effects of amikacin are similar to other aminoglycosides. Kidney damage and hearing loss are the most important effects. Because of this potential, blood levels of the drug and markers of kidney function (creatinine) may be monitored.


  • Edson RS, Terrell CL. The aminoglycosides. Mayo Clin Proc. 1999 May;74(5):519-28. Review. PMID 10319086

bg:Амикацин ca:Amikacina de:Amikacin es:Amikacina fa:آمیکاسین fr:Amikacine it:Amikacina nl:Amikacine pl:Amikacyna pt:Amicacina ru:Амикацин sl:Amikacin th:อะมิกาซิน zh:阿米卡星