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| class1 = [[Dihydrofolate reductase]] [[enzyme inhibitor|inhibitor]] (16.7%) Trimethoprim acts by interfering with the action of bacterial [[dihydrofolate reductase]], inhibiting synthesis of tetrahydrofolic acid.

...class of [[chemotherapy|chemotherapeutic]] agents known as [[dihydrofolate reductase inhibitor]]s. Trimethoprim was formerly marketed by [[GlaxoSmithKline]] und Trimethoprim acts by interfering with the action of bacterial [[dihydrofolate reductase]], inhibiting synthesis of [[folic acid|tetrahydrofolic acid]]. Tetrahydrof

...e Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2