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• Chloroquine
  ...to ~0.2% at a lysosomal pH of 4.6. Because the deprotonated form is more membrane-permeable than the protonated form, a quantitative "trapping" of the compou ...Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis a
  16 KB (2,187 words) - 16:41, 27 September 2010
• Rifampicin
  ...it, thus preventing transcription to [[RNA]] and subsequent translation to proteins.<ref>[http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20 ...''Mycobacterium tuberculosis''. Much of this acid-fast positive bacteria's membrane is [[mycolic acid]] complexed with [[peptidoglycan]], which allows easy mov
  18 KB (2,471 words) - 16:43, 27 September 2010
• Fluoxetine
  ...d in 6 to 8 hours. It is highly [[plasma protein binding|bound]] to plasma proteins, mostly [[human serum albumin|albumin]]. ...furthermore, they inhibit the activity of [[P-glycoprotein]], a type of [[membrane transport protein]] that plays an important role in drug transport and meta
  52 KB (7,168 words) - 16:47, 27 September 2010
• Dopamine
  ...In the prefrontal cortex, however, there are very few dopamine transporter proteins, and dopamine is instead inactivated by reuptake via the [[norepinephrine t ...n via its dopamine transporters as well as by diffusing through the neural membrane directly.{{Citation needed|date=April 2010}} By entering the presynaptic ne
  48 KB (6,470 words) - 16:48, 27 September 2010
• Glucose
  ...0095-8301}}</ref> In contrast, [[enzyme]]-regulated addition of glucose to proteins by [[glycosylation]] is often essential to their function.{{Citation needed ...hate]] group so the [[glucose 6-phosphate]] cannot easily cross the [[cell membrane]]. Irreversible first steps of a metabolic pathway are common for regulator
  23 KB (3,050 words) - 16:52, 27 September 2010
• Cortisol
  ...f> by decreasing the translocation of [[glucose transporter]]s to the cell membrane,<ref>{{Cite book|last=King|first= Michael W.|title=Lange Q&A USMLE Step 1|e ...le=Decreased intestinal calcium absorption in vivo and normal brush border membrane vesicle calcium uptake in cortisol-treated chickens: evidence for dissociat
  41 KB (5,644 words) - 16:50, 27 September 2010
• Tetracycline
  ...e to tetracyclines can arise through drug [[efflux]], ribosomal protection proteins, 16S rRNA mutation, and drug inactivation through the action of a monooxyge ...rboring the bacterial tet^r gene, which encodes a 399-amino acid membrane-associated protein. This protein actively exports tetracycline out of the c
  11 KB (1,417 words) - 21:55, 19 September 2010
• Poloxamer
  ...and other drug efflux transporters on the surface of cancer cells, the MDR proteins are responsible for the efflux of drugs from the cells and hence increase t ...-drug resistant (MDR) cancer cells. The polymers seem to inhibit respatory proteins I and IV, the effect on respiration seems to be selective for MDR cancer ce
  5 KB (782 words) - 10:09, 20 September 2010
• Biopolymer
  ...ese units are arranged is called the [[primary structure]], in the case of proteins. Many biopolymers spontaneously fold into characteristic compact shapes (se Stupp, S.I and Braun, P.V., "Role of Proteins in Microstructural Control: Biomaterials, Ceramics & Semiconductors", Scien
  68 KB (9,959 words) - 10:10, 20 September 2010
• Arabinogalactan
  ...larke AE|year=2000|title=Cell and developmental biology of arabinogalactan-proteins|publisher=Kluwer Academic/Plenum Publishers|id= ISBN 0-306-4649-1}}</ref> ...f arabinogalactan is covalently attached to the mycolic acids of the outer membrane. The hydrophobicity of mycolic acids is a barrier to drug entry. Additional
  6 KB (862 words) - 10:10, 20 September 2010
• Polyprenol
  ...portant role in maintenance of the correct [[lipid]] composition of [[cell membrane|membranes]]. Decreased levels of [[dolichol]]s are registered with acute [[ The [[dolichol]] phosphate cycle facilitates the process of cellular membrane [[glycosylation]], that is, the synthesis of [[glycoproteins]] that control
  9 KB (1,206 words) - 10:11, 20 September 2010
• Emulsion
  ...persion of the phase in which they do not dissolve very well; for example, proteins dissolve better in water than in oil and so tend to form oil-in-water emuls ...]] and [[blood cells]], which are vulnerable to nanoemulsions due to their membrane structures. For this reason, these nanoemulsions are not currently used [[i
  16 KB (2,286 words) - 10:12, 20 September 2010
• Colloid
  ...eir own dimension. The smaller the size of the pore of the ultrafiltration membrane, the lower the concentration of the dispersed colloidal particules remainin ...nan]] are extracted from seaweed, [[gelatin]] is produced by hydrolysis of proteins of [[bovinae|bovine]] and fish origins, and [[pectin]] is extracted from [[
  27 KB (3,735 words) - 10:13, 20 September 2010
• Ethylene oxide
  ...thylene oxide a universal poison for [[protoplasm]]: it causes clotting of proteins, deactivation of [[enzyme]]s and other biologically important components of ...in the air about 200 parts per million, ethylene oxide irritates [[mucous membrane]]s of the nose and throat; higher contents cause damage to the trachea and
  82 KB (11,709 words) - 21:31, 20 September 2010
• Panton-Valentine leukocidin
  Its genes secrete two proteins&mdash;toxins designated LukS-PV and LukF-PV, 33 and 34 kDa in size. These act together as subunits, assembling in the membrane of host defense cells, in particular, [[white blood cells]], [[monocytes]],
  9 KB (1,175 words) - 21:33, 20 September 2010
• Formaldehyde
  ...]] tissue or cells by reversibly cross-linking primary [[amino group]]s in proteins with other nearby nitrogen atoms in protein or [[DNA]] through a -CH<sub>2< ...above 0.1&nbsp;ppm in air formaldehyde can irritate the eyes and [[mucous membrane]]s, resulting in watery eyes.<ref>{{citation | title = Formaldehyde | url =
  34 KB (4,726 words) - 21:35, 20 September 2010
• Lead poisoning
  ...ne system]], causing production of excessive [[inflammation|inflammatory]] proteins; this mechanism may mean that lead exposure is a risk factor for [[asthma]] ...to be surgically removed if they are in or near fluid-filled or [[Synovial membrane|synovial]] spaces.<ref name="Kosnett06-241">[[#CITEREFKosnett06Pois|Kosnett
  90 KB (13,109 words) - 21:36, 20 September 2010
• Hemoglobin
  ...n the manner of letters in a written sentence or beads on a string. In all proteins, it is the variation in the type of amino acids in the protein sequence of ...e is more than one hemoglobin gene. The amino acid sequences of the globin proteins in hemoglobins usually differ between species, although the differences gro
  67 KB (9,844 words) - 20:17, 21 September 2010
• List of dog diseases
  ...pillary membrane]] is a condition of the eye involving remnants of a fetal membrane that persist as strands of tissue crossing the pupil.<ref name=Gelatt_1999/ ...n intestinal disease of dogs characterized by chronic diarrhea and loss of proteins such as [[serum albumin]] and [[globulin]]. It is considered to be a chroni
  99 KB (14,444 words) - 21:22, 3 October 2011
• Phosphate homeostasis
  ...acellular]] region near the [[Cell membrane|plasma membrane]], portions of membrane-associated molecules wait to capture [[phosphate]] and transport it into th ...ef name=Csapo>{{ cite journal |author=Joseph Csapo |title=The Influence of Proteins on the Solubility of Calcium Phosphate |journal=J Biol Chem. |volume=75 |is
  63 KB (9,050 words) - 21:26, 21 September 2010

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