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• Spectinomycin
  ...[[ribosome|ribosomal]] subunit in invading bacteria and interrupts protein synthesis. ...|author=Kehrenberg C, Schwarz S |title=Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multo
  3 KB (327 words) - 16:41, 27 September 2010
• Dexamethasone
  * Muscle atrophy, negative protein balance ([[catabolism]]) ==Synthesis==
  18 KB (2,498 words) - 16:41, 27 September 2010
• Clindamycin
  ...s]]).<ref>{{cite journal |author=Gemmell CG, O'Dowd A |title=Regulation of protein A biosynthesis in Staphylococcus aureus by certain antibiotics: its effect Clindamycin has a [[bacteriostatic]] effect. It is a bacterial [[protein synthesis inhibitor]] by inhibiting [[ribosomal translocation]],<ref>[http://sitemake
  25 KB (3,261 words) - 14:17, 11 September 2010
• Chloramphenicol
  Because it functions by inhibiting bacterial [[protein]] synthesis, chloramphenicol has a very broad spectrum of activity: it is active agains ...y lipid soluble, it remains relatively [[plasma protein binding|unbound to protein]] and is a small molecule: it has a large apparent [[volume of distribution
  29 KB (3,876 words) - 16:42, 27 September 2010
• Erythromycin
  ...roup, posthumously reported the first stereocontrolled asymmetric chemical synthesis of Erythromycin A. == Synthesis ==
  19 KB (2,731 words) - 17:52, 18 September 2010
• Gentamicin
  ...ng the [[30S]] subunit of the bacterial [[ribosome]], interrupting protein synthesis. ...lure]].<ref>Sundin DP, Sandoval R, Molitoris BA: Gentamicin Inhibits Renal Protein and Phospholipid Metabolism in Rats: Implications Involving Intracellular T
  9 KB (1,199 words) - 16:43, 27 September 2010
• Vancomycin
  Vancomycin biosynthesis occurs via different nonribosomal protein synthases (NRPSs).<ref name="pmid18414736">{{cite journal |author=Samel SA, ...6">{{cite journal |author=Kohli RM, Walsh CT, Burkart MD |title=Biomimetic synthesis and optimization of cyclic peptide antibiotics |journal=Nature |volume=418
  31 KB (4,198 words) - 16:43, 27 September 2010
• Rifampicin
  ...inia virus: effects of rifampin on the intracellular distribution of viral protein p65 |journal=J. Virol. |volume=68 |issue=2 |pages=1103–14 |year=1994 |mon ...n interacts with the β subunit of RNA polymerase when it is in an α2β [[protein trimer|trimer]]. This halts [[messenger rna|mRNA]] [[Transcription (genetic
  18 KB (2,471 words) - 16:43, 27 September 2010
• Isoniazid
  ...11 | year = 1972 | doi = 10.1007/BF00771896 | pages = 696–698 | title = Synthesis of isoniazid from 4-cyanopyridine | author = T. P. Sycheva, T. N. Pavlova a ...trate and the action of [[fatty acid synthase]]. This process inhibits the synthesis of [[mycolic acid]], required for the [[mycobacterium|mycobacterial]] cell
  12 KB (1,566 words) - 16:43, 27 September 2010
• Streptomycin
  Streptomycin is a [[protein synthesis inhibitor]]. It binds to the S12 Protein of the 30S subunit of the bacterial ribosome, interfering with the binding | title = Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome
  9 KB (1,069 words) - 15:06, 6 July 2010
• Kanamycin
  ...n synthesis]]<ref>Pestka, S.: "The Use of Inhibitors in Studies on Protein Synthesis", Methods in Enzymology 30, pp.261-282, 1975</ref><ref>Misumi, M. & Tanaka, ...f> is native to a plant species, of comparatively large size and its coded protein acts in a manner which decreases the possibility of [[Horizontal Gene Trans
  4 KB (503 words) - 16:44, 27 September 2010
• Ciprofloxacin
  ...s that cause DNA to rewind after being copied, which stops DNA and protein synthesis. ...ides, Mercapto-1,2,4-triazole, Oxadiazoline and α-Amino Ester Precursors: Synthesis and Antimicrobial Activity |journal=J. Braz. Chem. Soc |volume=14 |issue=5
  88 KB (11,930 words) - 16:46, 27 September 2010
• Azithromycin
  ...inhibits [[translation (biology)|translation]] of [[mRNA]]. Nucleic acid synthesis is not affected.
  15 KB (2,008 words) - 16:46, 27 September 2010
• Metformin
  First [[chemical synthesis|synthesized]] and found to reduce blood sugar in the 1920s, metformin was f ...fic literature in 1922, by Emil Werner and James Bell, as a product in the synthesis of ''N'',''N''-dimethylguanidine.<ref name = werner>{{vcite journal |author
  66 KB (8,976 words) - 16:47, 27 September 2010
• Aspirin
  ...to prepare acetylsalicylic acid in 1853. In the course of his work on the synthesis and properties of various [[acid anhydride]]s, he mixed [[acetyl chloride]] ...d [[thromboxane]]s.<ref>{{Cite journal|title = Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs|author = John Robert Vane|
  78 KB (10,918 words) - 16:52, 27 September 2010
• Dopamine
  In [[neuron]]s, dopamine is packaged after synthesis into [[Vesicle (biology)|vesicles]], which are then released into the [[syn ...[[polymerisation|polymerise]] and [[condense]] with [[amino acid]]s and [[protein]]s to form brown [[biological pigment|pigments]] known as [[melanin]]s. The
  48 KB (6,470 words) - 16:48, 27 September 2010
• Glucose
  ...ose sugars, to react non-specifically with the [[amine|amino]] groups of [[protein]]s. This reaction ([[glycation]]) reduces or destroys the function of many Glucose is critical in the production of [[protein]]s and in [[lipid]] metabolism. In plants and most animals, it is also a [[
  23 KB (3,050 words) - 16:52, 27 September 2010
• Cortisol
  ...gar]] through gluconeogenesis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism.<ref>First Aid USMLE Step 1 2009, Tao Le et al ....<ref>{{cite pmid|17426391}}</ref> However cortisol increases [[glycogen]] synthesis ([[glycogenesis]]) in the [[liver]].<ref>Baynes, J., Dominiczak, M., Medica
  41 KB (5,644 words) - 16:50, 27 September 2010
• Ibuprofen
  ...uresis]] is theoretically beneficial. However, because ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. For ===Synthesis===
  29 KB (3,955 words) - 22:17, 21 September 2010
• Epinephrine
  ...m ions to enter the cytoplasm. Calcium ions bind to calmodulin proteins, a protein present in all eukaryotic cells, which then binds to Phosphorylase Kinase a ...increases the expression of PNMT in chromaffin cells, enhancing adrenaline synthesis. This is most often done in response to stress.{{Citation needed|date=April
  22 KB (2,916 words) - 16:50, 27 September 2010

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