Difference between revisions of "Mebendazole"

Latest revision as of 15:42, 27 September 2010

Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Mechanism

Mebendazole is thought to kill worms by selectively inhibiting the synthesis of microtubules, impairing the parasite's ability to utilise glucose.Mebendazole slowly immobilize and kills parasitic worms probably by inhibiting their micro tubular transport system. It is also believed that it acts by destroying the cytoplasmic micro tubes in the worm's intestinal cells thereby blocking uptake of glucose and other nutrients resulting to death of the helminth. It is a highly effective broad spectrum anti elminitic indicated for the treatment of nemotode infestations including round worm, whip worm,thread worm and hook worm. It is poorly absorbed and has no systematic effects.

Dosage

Oral dosage for treatment of pinworms is 100 mg per dose, with one dose taken every two weeks.^{[citation needed]} This regimen is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.^{[citation needed]}

Adverse Reactions - Side Effects : Transient abdominal pain,diarrhea,slight headache,fever,dizziness,exanthema, urticaria and angioedema.

Drug interactions

Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.^[1]

Stevens-Johnson syndrome (toxic epidermal necrolysis) when mebendazole is combined with high doses of metronidazole.^[2]

See also

• Metronidazole

References

External links

• Vermox (UK manufacturer's website)

de:Mebendazol es:Mebendazol fa:مبندازول fr:Mébendazole hu:Mebendazol nl:Mebendazol pl:Mebendazol pt:Mebendazol ru:Мебендазол

1. ↑ "Drug Interactions". Retrieved 2008-05-06. . /// Luder PJ, et al. Treatment of hydatid disease with high oral doses of mebendazole: long-term follow-up of plasma mebendazole levels and drug interactions. Eur J Clin Pharmacol 1986; 31: 443–8
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