Difference between revisions of "Mebendazole"

Revision as of 14:06, 6 July 2010

Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Mechanism

Mebendazole is thought to cause slow immobilization and death of the worms by selectively inhibiting the synthesis of microtubules.

Dosage

Oral dosage for treatment of pinworms is 100 mg per dose, with one dose taken every two weeks.^{[citation needed]} This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.^{[citation needed]}

Drug interactions

Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.^[1]

Stevens-Johnson syndrome (toxic epidermal necrolysis) when mebendazole is combined with high doses of metronidazole.^[2]

See also

• Metronidazole
• Janssen Pharmaceutica
• K. A. Malle Pharmaceuticals Limited

External links

• Vermox (UK manufacturer's website)
• K. A. Malle Pharmaceuticals Limited (Indian manufacturer's website)

References

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1. ↑ "Drug Interactions". Retrieved 2008-05-06. . /// Luder PJ, et al. Treatment of hydatid disease with high oral doses of mebendazole: long-term follow-up of plasma mebendazole levels and drug interactions. Eur J Clin Pharmacol 1986; 31: 443–8
2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.