Difference between revisions of "Mebendazole"

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| IUPAC_name = methyl (5-benzoyl-1''H''-benzimidazol-2-yl)carbamate
 
| IUPAC_name = methyl (5-benzoyl-1''H''-benzimidazol-2-yl)carbamate
 
| image = Mebendazol.svg
 
| image = Mebendazol.svg
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| width = 320
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| width = 200
 
| CASNo_Ref = {{cascite}}
 
| CASNo_Ref = {{cascite}}
 
| CAS_number=31431-39-7
 
| CAS_number=31431-39-7
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| molecular_weight = 295.293 g/mol
 
| molecular_weight = 295.293 g/mol
 
| melting_point = 288.5
 
| melting_point = 288.5
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| bioavailability= ?
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| bioavailability=  
 
| metabolism = Hepatic
 
| metabolism = Hepatic
 
| elimination_half-life= 2.5 to 5.5 hours
 
| elimination_half-life= 2.5 to 5.5 hours
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| excretion = ?
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| excretion =  
 
| pregnancy_category = C
 
| pregnancy_category = C
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| legal_status = ?
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| legal_status =  
 
| routes_of_administration= Oral
 
| routes_of_administration= Oral
 
}}
 
}}
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'''Mebendazole''' or '''MBZ''', marketed as Ovex, Vermox, Antiox, Pripsen, is a [[benzimidazole]] drug that is used to treat infestations by [[worm]]s including [[pinworm]]s, [[roundworm]]s, [[tapeworm]]s, [[hookworm]]s, and [[whipworm]]s.
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 +
'''Mebendazole''' or '''MBZ''' is a [[benzimidazole]] drug developed by [[Janssen Pharmaceutica]] and marketed as Vermox, Ovex, Antiox, and Pripsen.  It is used to treat infestations by [[worm]]s including [[pinworm]]s, [[roundworm]]s, [[tapeworm]]s, [[hookworm]]s, and [[whipworm]]s.
  
 
==Mechanism==
 
==Mechanism==
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Mebendazole is thought to cause slow immobilization and death of the worms by selectively inhibiting the synthesis of microtubules.
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Mebendazole is thought to kill worms by selectively inhibiting the synthesis of microtubules, impairing the parasite's ability to utilise [[glucose]].
  
 
==Dosage==
 
==Dosage==
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Oral dosage for treatment of pinworms is 100 [[milligram|mg]] per dose, with one dose taken every two weeks.{{Fact|date=June 2009}} This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with.  Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms.
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Oral dosage for treatment of pinworms is 100 [[milligram|mg]] per dose, with one dose taken every two weeks.{{Fact|date=June 2009}} This regimen is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with.  Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms.
 
Dosage on the packaging of some products suggests that 100&nbsp;mg is a suitable single dose tablet. However using this minimal dose may be ineffective.{{Fact|date=June 2009}}<!--My MD (In Massachusetts) and Pharmacist (RiteAid) prescribed only two 100mg tablets, one to be taken immediately and one to be taken in two weeks. For Pinworm in my 3yo girl. I think the info in this section is inaccurate or accurate only for some type of parasites and not others. Bad info about dosage is pretty serious  -->
 
Dosage on the packaging of some products suggests that 100&nbsp;mg is a suitable single dose tablet. However using this minimal dose may be ineffective.{{Fact|date=June 2009}}<!--My MD (In Massachusetts) and Pharmacist (RiteAid) prescribed only two 100mg tablets, one to be taken immediately and one to be taken in two weeks. For Pinworm in my 3yo girl. I think the info in this section is inaccurate or accurate only for some type of parasites and not others. Bad info about dosage is pretty serious  -->
  
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== See also ==
 
== See also ==
 
* [[Metronidazole]]
 
* [[Metronidazole]]
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* [[Janssen Pharmaceutica]]
 
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* [[K. A. Malle Pharmaceuticals Limited]]
 
  
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== External links ==
 
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* [http://www.janssen-cilag.co.uk/product/detail.jhtml?itemname=vermox_info&s=0&_requestid=668627 Vermox] (UK manufacturer's website)
 
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* [http://www.kamalle.com K. A. Malle Pharmaceuticals Limited] (Indian manufacturer's website)
 
 
== References ==
 
== References ==
 
{{reflist|2}}
 
{{reflist|2}}
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 +
== External links ==
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* [http://www.janssen-cilag.co.uk/product/detail.jhtml?itemname=vermox_info&s=0&_requestid=668627 Vermox] (UK manufacturer's website)
  
 
{{Anthelmintics}}
 
{{Anthelmintics}}
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{{pharma-stub}}
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{{antiinfective-drug-stub}}
  
 
[[cs:Mebendazol]]
 
[[cs:Mebendazol]]

Revision as of 05:32, 26 August 2010

"MBZ" redirects here. For the automobile brand abbreviated as "MBZ", see Mercedes-Benz.
Mebendazole
200px
Systematic (IUPAC) name
methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
Clinical data
Pregnancy
category
  • C
Routes of
administration		 Oral
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 2.5 to 5.5 hours
Identifiers
CAS Number 31431-39-7
ATC code P02CA01 (WHO) QP52AC09
PubChem CID 4030
DrugBank APRD01086
ChemSpider 3890
Chemical data
Formula C16H13N3O3
Molar mass 295.293 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Physical data
Melting point 288.5 °C (551.3 °F)
  (verify)
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Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Mechanism

Mebendazole is thought to kill worms by selectively inhibiting the synthesis of microtubules, impairing the parasite's ability to utilise glucose.

Dosage

Oral dosage for treatment of pinworms is 100 mg per dose, with one dose taken every two weeks.[citation needed] This regimen is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.[citation needed]

Drug interactions

Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.[1]

Stevens-Johnson syndrome (toxic epidermal necrolysis) when mebendazole is combined with high doses of metronidazole.[2]

See also

References

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External links

  • Vermox (UK manufacturer's website)
Antiplatyhelmintic agents
Binds tubulin
Other/unknown
Binds tubulin
Other/unknown
Antinematodal agents
(including
macrofilaricides)
Binds tubulin
Other/unknown


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cs:Mebendazol

de:Mebendazol es:Mebendazol fa:مبندازول fr:Mébendazole hu:Mebendazol nl:Mebendazol pl:Mebendazol pt:Mebendazol ru:Мебендазол sk:Mebendazol

sv:Mebendazol
  1. ↑ "Drug Interactions". Retrieved 2008-05-06. . /// Luder PJ, et al. Treatment of hydatid disease with high oral doses of mebendazole: long-term follow-up of plasma mebendazole levels and drug interactions. Eur J Clin Pharmacol 1986; 31: 443–8
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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