Tribendimidine

Tribendimidine
	File:Tribendimidine.svg
Systematic (IUPAC) name
	N,N'-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4; -phenylene dimethylidyneamine
Identifiers
CAS Number	115103-15-6
ATC code	none
PubChem	CID 3086564
Chemical data
Formula	C28H32N6
Molar mass	452.594 g/mol[[Script error: No such module "String".]]

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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.^[1]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.^[2] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.^[1]

References

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↑ ^1.0 ^1.1 Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrob Agents Chemother. 51 (3): 1096–8. doi:10.1128/AAC.01366-06. PMC 1803157 Freely accessible. PMID 17194822. Free full text
↑ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Trop. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.