Abafungin

Abafungin
	File:Abafungin.png
Systematic (IUPAC) name
	N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
Clinical data
Routes of; administration	topical
Identifiers
CAS Number	129639-79-8
ATC code	none
PubChem	CID 159326
Chemical data
Formula	C21H22N4OS
Molar mass	378.491 g/mol[[Script error: No such module "String".]]
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Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.^[1]

Mechanism of action

Like imidazole- and triazole-class antifungals, abafungin inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane.

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity. ^[2]

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↑ York Pharma: Regulatory Update – Abasol
↑ Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103