Terutroban

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Terutroban
Systematic (IUPAC) name
File:Terutroban structure.svg
Sodium 3-((6R)-6-{[(4-chlorophenyl)sulfonyl]amido}-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoate
Clinical data
Routes of administration	Oral
Legal status
Legal status	Investigational
Pharmacokinetic data
Biological half-life	6-10 hours

Identifiers
ATC code	none
PubChem	CID 23674098
Chemical data
Formula	C₂₀H₂₁ClNNaO₄S
Molar mass	429.892 g/mol[[Script error: No such module "String".]]
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Terutroban is an antiplatelet agent developed by Servier Laboratories. As of 2008^[update], it is tested for the secondary prevention of acute thrombotic complications in the Phase III clinical trial PERFORM.

Method of action

Terutroban is a selective antagonist of the thromboxane receptor. It blocks thromboxane induced platelet aggregation and vasoconstriction.

H. Spreitzer (January 29, 2007). "Neue Wirkstoffe - Terutroban". Österreichische Apothekerzeitung (in German) (3/2007): 116.
Sorbera, LA, Serradell, N, Bolos, J, Bayes, M (2006). "Terutroban sodium". Drugs of the Future. 31 (10): 867–873. doi:10.1358/dof.2006.031.10.1038241.

Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
ADP receptor/P2Y₁₂ inhibitors	thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • Ticagrelor^†
Prostaglandin analogue (PGI2)	Beraprost • Prostacyclin • Iloprost • Treprostinil
COX inhibitors	Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal
Thromboxane inhibitors	thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)
Phosphodiesterase inhibitors	Cilostazol • Dipyridamole • Triflusal
Other	Cloricromen • Ditazole

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low molecular weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) oligosaccharides (Fondaparinux, Idraparinux) heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)
Direct Xa inhibitors	xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)