Turosteride

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Turosteride
File:Turosteride structure.png
Systematic (IUPAC) name
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-1,4a,6a-trimethyl-2-oxo-N-(propan-2-yl)-N-(propan-2-ylcarbamoyl)hexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 137099-09-3
ATC code none
PubChem CID 65986
ChemSpider 59380
Synonyms 1-(4-methyl-3-oxo-4-aza-5-alpha-androstane-17-beta-carbonyl)-1,3- diisopropylurea
Chemical data
Formula C27H45N3O3
Molar mass 459.66 g/mol[[Script error: No such module "String".]]
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Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-redcutase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH) but was never marketed.[1][2][3] Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme.[4][5] In animal studies it has been shown to inhibit prostate size and retard tumor growth.[2][3][6][7] It may also be useful for the treatment of acne and hair loss.[8][9][10]

See also

References

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5α-reductase inhibitors
Alpha blockers (α1)
Herbals
Other dermatological preparations (D11)
Medicated shampoos
Cetrimide - Cadmium compounds - Selenium compounds - Povidone-iodine - Sulfur compounds - Xenysalate
Other dermatologicals
Other
  1. ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
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  8. ↑ Rawlings, Anthony V.; Webster, Guy F. (2007). Acne and its therapy. New York: Informa Healthcare USA. ISBN 0-8247-2971-4. 
  9. ↑ "Hairloss Treatment: Turosteride". 
  10. ↑ "Hair Loss Drugs - Turosteride - competitive and specific inhibitor of Type II 5a-reductase. - Database of Drugs for Hair Loss". 
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