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Systematic (IUPAC) name
Clinical data
Routes of
Legal status
Legal status
Pharmacokinetic data
Bioavailability 100% (oral)
Metabolism hepatic
Biological half-life 9–13 hours
Excretion 76% renal
CAS Number 106133-20-4
ATC code G04CA02 (WHO)
PubChem CID 129211
DrugBank APRD00036
ChemSpider 114457
Chemical data
Formula C20H28N2O5S
Molar mass 408.51[[Script error: No such module "String".]]
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Tamsulosin (rINN) (pronounced /tæmˈsuːlɵsɨn/ or tæmsʉˈloʊsɨn) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. Tamsulosin hydrochloride extended-release capsules are marketed under the trade names Flomax, Flomaxtra and Urimax, though generic non-modified release capsules are still approved and marketed in many countries, such as Canada. The U.S. patent for Flomax expired October 2009.

In Egypt [1] and Iceland it is marketed under the trade Omnic by Astellas pharma europe.


Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels.[2]

Clinical uses

Tamsulosin is primarily used for benign prostatic hyperplasia, but is sometimes used for the passage of kidney stones by the same mechanism of smooth muscle relaxation via alpha antagonism.[citation needed]

Adverse effects

Two ADRs (Adverse Drug Reactions) have been reported:

Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation.[citation needed] In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly.

Occasionally, tamsulosin can cause a drop in blood pressure, rarely resulting in dizziness or fainting.[citation needed] Other reported side effects include headache, dizziness, nasal congestion, and palpitations.[citation needed]

Clinical comparison

Although prostate specific, it does not have the prostate apoptotic effects of other alpha-blockers such as doxazosin and terazosin.[citation needed]

Use in combination therapy

The results of the CombAT (Combination of Avodart and Tamsulosin) trial have recently demonstrated that treatment with the combination of Avodart and tamsulosin provides superior symptom benefits compared with either monotherapy.[4]


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External links


fr:Tamsulosine it:Tamsulosin ja:タムスロシン

  1. "Novartis hits Astellas with transplant drug generic". Reuters. 11 August 2009. Retrieved 11 August 2009. 
  2. Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 13. ISBN 1-59541-101-1. 
  3. Medscape, Good Cataract Surgery Outcomes Possible in Intraoperative Floppy Iris Syndrome Due to Tamsulosin
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