|Systematic (IUPAC) name|
|Biological half-life||9–13 hours|
|ATC code||G04CA02 (WHO)|
|Molar mass||408.51[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
Tamsulosin (rINN) (pronounced /tæmˈsuːlɵsɨn/ or tæmsʉˈloʊsɨn) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. Tamsulosin hydrochloride extended-release capsules are marketed under the trade names Flomax, Flomaxtra and Urimax, though generic non-modified release capsules are still approved and marketed in many countries, such as Canada. The U.S. patent for Flomax expired October 2009.
In Egypt  and Iceland it is marketed under the trade Omnic by Astellas pharma europe.
Tamsulosin is primarily used for benign prostatic hyperplasia, but is sometimes used for the passage of kidney stones by the same mechanism of smooth muscle relaxation via alpha antagonism.
Two ADRs (Adverse Drug Reactions) have been reported:
- Immunologic: It contains a sulfa moiety, thus causing typical reactions to sulfa drugs.
- Ophthalmologic: Patients taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the patient's history with this drug, and thus having the option of alternative techniques.
Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation. In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly.
Occasionally, tamsulosin can cause a drop in blood pressure, rarely resulting in dizziness or fainting. Other reported side effects include headache, dizziness, nasal congestion, and palpitations.
Use in combination therapy
The results of the CombAT (Combination of Avodart and Tamsulosin) trial have recently demonstrated that treatment with the combination of Avodart and tamsulosin provides superior symptom benefits compared with either monotherapy.
Cite error: Invalid
parameter "group" is allowed only.
<references />, or
<references group="..." />
- Tamsulosin – information from USP DI Advice for the Patient
- Flomax (drugs.com) – U.S. product information
- Flomax (Official Site) – Official Site
- "Novartis hits Astellas with transplant drug generic". Reuters. 11 August 2009. Retrieved 11 August 2009.
- Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 13. ISBN 1-59541-101-1.
- Medscape, Good Cataract Surgery Outcomes Possible in Intraoperative Floppy Iris Syndrome Due to Tamsulosin
- Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.