Search results

...injury, it is reasonable to suppose that such events may contribute to the clinical neuropathy of the drug."<ref name="Dow2004" /> 1. "At the time this study was conceived, no formal FDA guidelines for neurotoxicity testing existed.

...erative removal of impacted third molar teeth |journal=European Journal of Clinical Pharmacology |volume=44 |issue=3 |pages=275–277 |year=2004 |pmid= 8491244 ...ino T, Ichijo T, Chrousos GP |title=Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder

==Clinical use== ...d reactions to intravenous N-acetylcysteine: a prospective case controlled study |journal=Accid Emerg Nurs |volume=12 |issue=1 |pages=10–5 |year=2004 |mon

...on of therapy.<ref>{{cite book|last=Bauer |first=Larry A. |title=[[Applied Clinical Pharmacokinetics]] |edition=2^nd |year=2008 |publisher=[[McGraw-H ...ting effect on the peripheral auditory system: auditory brainstem response study |journal=J. Child Neurol. |volume=19 |issue=6 |pages=453–5 |year=2004 |mo

| authorlink = National Institute for Health and Clinical Excellence ...leptic attacks were susceptible to the drug. Hauptmann performed a careful study of his patients over an extended period. Most of these patients were using

...emarkable Medicine Has Been Overlooked: Including an Autobiography and the Clinical Section of the Broad Range of Use of Phenytoin |publisher=Continuum Interna ...oughts compared to placebo-takers. Although phenytoin was not named in the study, the FDA announced that it expected the risk applied to every epilepsy drug

==Clinical use== ...[[fluorouracil]] to treat [[colon cancer]]. There is no good evidence from clinical trials that its addition to fluorouracil therapy benefits patients with col

A study found that the antibiotic [[rifampicin]] decreases plasmatic concentrations ...l.<ref>{{cite journal |author=Quinn DI, Day RO |title=Drug interactions of clinical importance. An updated guide |journal=Drug Saf |volume=12 |issue=6 |pages=3

...97)70177-4}}</ref> A [[blind experiment#Single-blind trials|single-blind]] study comparing this combination to [[adapalene]], a [[retinoid]], also found it ...ear=2003 |pmid=12963897|doi=10.1067/S0190-9622(03)01152-6}}</ref> a single study found [[wikt:pretreatment|pretreatment]] with adapalene (application of ada

...Wallerstein R, Condit P, Kasper C, Brown J, Morrison F | title = Statewide study of chloramphenicol therapy and fatal aplastic anemia. | journal = JAMA | vo ...k of childhood [[leukemia]] as demonstrated in a Chinese [[case-controlled study]],<ref>{{cite journal | author = Shu X, Gao Y, Linet M, Brinton L, Gao R, J

...ff A, Massung RF, Christensson B |title=Human granulocytic ehrlichiosis--a clinical case in Scandinavia |journal=Scand. J. Infect. Dis. |volume=33 |issue=1 |pa ...N, Erwin M, Sader HS |title=[Evaluation of antimicrobial sensitivity of 87 clinical isolates of vancomycin-resistant enterococci] |language=Portuguese |journal

A 2005 study found "Metronidazole therapy before 32 weeks was associated with an increas ...m birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study |journal=BJOG |volume=113 |issue=1 |pages=65–74 |year=2006 |pmid=16398774

...re mutually antagonistic ''in vitro''. It is not known whether this is of clinical significance, but the combination should be avoided. ...ef>{{cite journal | author=Richards WA, ''et al.'' | title=Nitrofurantoin: Clinical and laboratory studies in urinary tract infections | journal=Arch Intern Me

...nsed to various [[generic drug|generic pharmaceutical]] manufacturers. In clinical use it is often abbreviated '''TRI''' or '''TMP'''; its common laboratory a ...ve steps in folate synthesis. This claimed benefit was not seen in general clinical use.<ref>{{cite journal |author=Brumfitt W, Hamilton-Miller JM |title=Reass

==Clinical use== |title=Serum vancomycin concentrations: reappraisal of their clinical value

...olerate the effects of [[Dapsone]] for Tuberculosis.<ref name="ReferenceA">Clinical Microbiology Made Ridiculously Simple</ref> ...researcher named Chang identified its effectiveness against leprosy. After clinical trials in Nigeria and elsewhere during the 1960s, some sponsored by the Swi

...treatment of brown recluse spider envenomation: a double-blind, controlled study in a rabbit model. Arch Dermatol 2005; 141(5):595-7.</ref>; however, dapson

...Organisation|WHO]] recommend its use in pregnancy; and there is extensive clinical experience to show that it is safe. In the U.S., pyrazinamide is not used | title = Clinical and molecular analysis of patients with renal hypouricemia in Japan-influen

==Clinical use== HIV-1 progression can be delayed by using Aciclovir, according to study lead by Dr Jairam Lingappa. Effective in 16% of cases, can delay the HAART

...discovered accidentally when a patient took Zidovudine secretly while in a clinical trial of Lmivudine monotherapy. Dr. Yung-Chi Cheng of [[Yale University]] ...h level resistance, because the resistant virus is "less fit". The COLATE study has suggested that there is no benefit to continuing lamivudine treatment i

...s. There are no study results demonstrating the effect of tenofovir on the clinical progression of HIV. ...duced rate, the researchers cautioned against drawing conclusions from the study because the sample size was so small.<ref>

...|author= Patel SS, Benfield P |title=New drug profile: nevirapine |journal=Clinical Immunotherapeutics |volume=6|issue=4|pages=307–317 |year=1996 |month=Oct ...ed patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study |journal=JAMA |volume=279 |issue=12 |pages=930–7 |year=1998 |month=Mar |p

...tal reports state that lopinavir cannot be detected in the CSF; however, a study of paired CSF-plasma samples from 26 patients receiving lopinavir/ritonavir ...observed with lopinavir/ritonavir are [[diarrhea]] and [[nausea]]. In key clinical trials, moderate or severe diarrhea occurred in up to 27% of patients, and

...|last15=Schrenk |first15=UM |last16=Dieterich |first16=DT |last17=Apricot Study |first17=Group}}</ref> ...for HIV/AIDS patients. However, ribavirin has proven to have little if any clinical usefulness against HIV, and it can greatly increase blood levels and also t

...drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II |journal=Psychosomatics |volume=44 |issue=6 |pages=515–2 ...91, when the aforementioned organisation undertook its first comprehensive study of Schedule V and overall codeine, dihydrocodeine, ethylmorphine, and hydro

Ketamine was invented as CL369, and it was referred to as CI 581 (clinical investigation 581) during development at Parke-Davis.<ref name="Jansen23">{ ...al amitriptyline and ketamine in neuropathic pain syndromes: an open-label study |journal=The Journal of Pain |volume=6 |issue=10 |pages=644–9 |year=2005

...| last1 = Kawahara | first1 = S. | title = [Chemotherapeutic agents under study] | journal = Nippon Rinsho | volume = 56 | issue = 12 | pages = 3096–9 | .... Dikov |title=A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Of Antibiotics For The Treatment Of Category Iiib Chronic Pelvic Pain Syndr

...current Supreme Court challenges to the lethal injection protocol, after a study in the medical journal ''[[The Lancet]]'', where autopsy studies on execute ...D''] August 1997, AANA Archives-Library</ref> Dr. John S. Lundy started a clinical trial of thiopental at the [[Mayo Clinic]] at the request of Abbott.<ref>[h

...tive measure if taken daily or weekly leading up to exposure, though human clinical trials are ongoing [http://www.sfgate.com/cgi-bin/article.cgi?f=/n/a/2006/0 ==Clinical Studies==

}}</ref> especially due to its low price. Several clinical trials are in progress, trying to find a suitable drug combination. Initial | title=Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

...laborating Centre for Chronic Conditions | title=Type 2 diabetes: national clinical guideline for management in primary and secondary care (update) | location= ...in people, and in 1957, French physician Jean Sterne published the first [[clinical trial]] of metformin as a treatment for diabetes. It was introduced to the

'''Valproic acid''' ('''VPA''') is a [[chemical compound]] that has found clinical use as an [[anticonvulsant]] and [[mood stabilizer|mood-stabilizing]] [[med ...s and bipolar disorder.<ref>Henry T.R. (2003). The History of Valproate in Clinical Neuroscience. ''Psychopharmacology bulletin'' 37 (Suppl 2):5-16</ref>

...treatment of major depression: results of a placebo-controlled, randomized clinical trial |journal=J Clin Psychopharmacol |volume=20 |issue=4 |pages=423–7 |y ...Kinoshita T |title=ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder |journal=

...yocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial|journal = BMJ| volume = 313|issue = 7070|pages = 1429–1431|publishe ...Mortality, 1918%u20131919 Pharmacology, Pathology, and Historic Evidence. Clinical Infectious Diseases, 2009; DOI: 10.1086/606060</ref> Aspirin's profitabilit

==Clinical use== ...a]], [[dizziness]], trouble awakening and sleep deprivation, although in [[clinical trial]]s the incidence of these effects with omeprazole was mostly comparab

...lopment of [[breast]]s in [[man|men]] ([[gynecomastia]]), [[impotence]], [[Clinical depression|depression]], [[insomnia]], [[tachycardia]], [[gingival enlargem ...practice: results from the STRONG prospective, observational, multicenter study

== Clinical Use == ...t al. Do selected drugs increase the risk of lupus? A matched case-control study. Br J Clin Pharmacol. 2010 Oct;70(4):588-96. doi: 10.1111/j.1365-2125.2010.

...51/2/251}}</ref>. This negatively chronotropic effect is important for its clinical use in different arrhythmias (see below). ==Clinical use==

In one non-[[Randomized controlled trials|randomized]] study, simvastatin halved the risk of developing [[dementia]] or [[Parkinson's di ...s as well, simvastatin was the first statin drug to be used extensively in clinical practice.

...ire, and pleasure have come from studies performed on animals. In one such study, rats were depleted of dopamine by up to 99 percent in the [[nucleus accumb ...e rat's consummatory pleasure, only the desire to actually eat. In another study, mutant hyperdopaminergic (increased dopamine) mice show higher "wanting" b

...i-rejection regime, until [[ciclosporin|cyclosporine]] was introduced into clinical practice (also by Calne) in 1978. ...ssive regimens in renal transplantation: a systematic review and modelling study | journal=Health Technol Assess | volume=9 | issue=21 | pages=1–194 | yea

==Clinical use== ...ing drug for many years. When omeprazole and ranitidine were compared in a study of 144 people with severe inflammation and erosions or ulcers of the esopha

...of study data by the FDA showed that about 20 percent of patients in that study who used metoclopramide took it for longer than three months.<ref name="Abo ==Clinical use==

...l levels have been observed in connection with abnormal [[ACTH]] levels, [[clinical depression]], [[stress (psychology)|psychological stress]], and such physio ...A. (1965) “Antidiuretic Hormone in Adrenal Insufficiency”. Journal of Clinical Investigation 44: 1041,.</ref> and other different animal mechanisms operat

...s Handbook | isbn = 0-9578521-4-2 | author = | oclc = 224121065}}</ref> A study from 2010 has shown that regular use of NSAIDs was associated with an incre ...TJ. | title=Acute poisoning due to non-steroidal anti-inflammatory drugs. Clinical features and management. | journal= Med Toxicol | year=1986 | pages=12–31

...being engineered and produced already in 1794, the way was now paved for [[clinical trial]]s, which began when [[Thomas Beddoes]] in 1798 established the ''"Pn ...ts of feeling "high", but did not alter psycho-motor performance, in human clinical studies.<ref name="zacny">{{cite journal|title = Flumazenil may attenuate s

...to mercury thermometers and sphygmomanometers being largely phased out in clinical environments in favor of [[alcohol]]-filled, digital, or [[thermistor]]-bas ...alth from coal fired power plants' mercury emissions documented in the EPA Study Report to Congress of 1998.<ref name="nj vs epa">{{cite news|url=http://pac

...cers were caused by retroviruses, but this knowledge was of limited use in clinical settings due to a lack of drugs that were effective against them. The devel ...M198909143211106 | author=Yarchoan R, Mitsuya H, Myers C, Broder S | title=Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related di

In clinical medicine, morphine is regarded as the gold standard, or benchmark, of analg ...=http://books.google.com/?id=MtOiLVWBn8cC&pg=PA20|page=20|title=Molecular, clinical and environmental toxicology|author=Andreas Luch|publisher=Springer|year=20

...and New Zealand—explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres |j ...name=pmid17227290/> In 1893, von Mering published a paper reporting on the clinical results of paracetamol with [[phenacetin]], another aniline derivative.<ref

...tp://jpet.aspetjournals.org/content/148/2/158.abstract ''A pharmacological study of the ephedrine isomers''] JPET May 1965 vol. 148, no. 2, pp. 158-168.&nbs ...enturies.<ref name=Ford>Ford MD, Delaney KA, Ling LJ, Erickson T, editors. Clinical Toxicology. Philadelphia: WB Saunders; 2001. ISBN 0-7216-5485-1

* Severe [[clinical depression|depression]], particularly when accompanied by suicidal tendenci ...Hriscu | month = October-December | year = 2002 | title = [An experimental study of tolerance to benzodiazepines] | journal = Revista Medico-Chirurgicală̆

...ffeine: assessment of segmental sodium reabsorption in humans. | journal = Clinical Science | volume = 103 | year = 2002 | accessdate = 2010-06-18 | pages = 46 ...TA on coronary arteries is currently (2008) proceeding.<ref name="clinical study">http://www.clinicaltrials.gov/ct/show/NCT00044213?order=2</ref> EDTA pla

...nite poisoning.<ref>{{cite journal |author=Lin CC, Chan TY, Deng JF |title=Clinical features and management of herb-induced aconitine poisoning |journal=Ann Em ...goes 'samskaras' before being utilized in the Ayurvedic formulations. This study was undertaken in mice, to ascertain whether 'processed' aconite is less to

| title = Clinical and analytical studies of sheep dosed with various preparations of ''Astrag [[Medical diagnosis|Diagnosis]] of clinical poisoning is generally made by documenting exposure, identifying the neurol

...l<SUP>TM</SUP> in Patients with Advanced Solid Tumors. American Society of Clinical Oncology. Retrieved on 2009-07-27.]<!-- Bot generated title -->]</ref> a ra

...llic acid]].<ref>{{cite journal|author=Genova E, Komitska G, Beeva Y|title=Study on the germination of Atropa Bella-Donna L. Seeds|url=http://www.bio21.bas. ...n S, Lewith G, Bryant T |title=Ultramolecular homeopathy has no observable clinical effects. A randomized, double-blind, placebo-controlled proving trial of Be

...urnal of Midwifery Research and Practice. 2(2):22–27. (2003)</ref> and a clinical trial has shown that the juice is [[diuretic]] in patients with [[congestiv Nettle root extracts have been extensively studied in human clinical trials as a treatment for symptoms of [[benign prostatic hyperplasia]] (BPH

* Severe [[clinical depression|depression]], particularly when accompanied by suicidal tendenci ...|year=2004 |month= |title=Residual effects of hypnotics: epidemiology and clinical implications |journal=CNS Drugs |volume=18 |issue=5 |pages=297–328 |pmid=

...About Nystagmus |accessdate = 2007-06-07 |work=}}</ref> Authors of another study in the United Kingdom estimated an incidence of 24 in 10,000, noting an app Clinical trials of a surgery to treat nystagmus (known as tenotomy) concluded in 200

In an epidemiologic study by Krause et al., 56% of patient’s with Behçet's disease developed ocula ...ging (MRI) in some patients with acute optic neuropathy. However, a normal study does not rule out optic neuropathy. Cerebrospinal fluid (CSF) analysis may

..., while only 3-5% will develop severe ophthalmopathy.<ref>Pathogenesis and clinical features of Graves' ophthalmopathy (orbitopathy) Terry F Davies, MD (Author ...Ultrasonography]] may detect early Graves' orbitopathy in patients without clinical orbital findings. It is less reliable than the [[CT scan]] and [[magnetic r

==Clinical use== ...he kidneys to retain potassium, which may lead to [[hyperkalemia]]. From a study of more than 1,000 patients who have hyperkalemia when using Lisinopril, th

...relan'''). It was undergoing [[clinical trial#Phase III|Phase&nbsp;III]] [[clinical trial]]s {{as of|2008|lc=on}},<ref>http://www.acorda.com/pipeline_fampridin ...ailure. Potassium channel blockade reverses this effect. However, a recent study has shown that 4-AP is a potent calcium channel activator and can improve s

..., making controlled clinical tests difficult, and the results of any given study cannot be reliably extrapolated to propolis samples from other areas. ...ss of propolis for [[immunostimulant|immunostimulation]]: a clinical pilot study

==Clinical uses== A study published in the journal ''Hepato-Gastroenterology'' (Chiba T, Kudara N, Sa

...complicated way on their primary structures. [[Structural biology]] is the study of the structural properties of the biopolymers. ...of degradation should follow for the crosslinked portion of the polymer. A study of the effects of UV irradiation on hydrolyzable polymers confirmed this. S

...pi.nwsource.com/health/202292_spinal04.html|date = 4 December 2004|title = Study on dogs yields hope in human paralysis treatment|author = Lee Bowman|publis ===Research for new clinical uses===

...the National Eczema Society (Exchange) December 1994, (75), 16-17</ref> A study carried out at New York University Hospital in the early 1950’s had shown ...dryness and scaling, cracks and abrasions, and pain and itch.8 In another study, a high purity grade of lanolin was found to be significantly superior to

...of Nutrition 45(8):470-7.</ref> This has been demonstrated in a clinical study, where the daily ingestion of flaxseed oil decreased the endogenous product

...rt B, Critical reviews}}</ref> were observed in at least one well-designed study with detailed exposure assessment, but were not consistently observed acros

...nteers |volume=24 |issue=1 |pages=23–5 |journal=International journal of clinical pharmacology, therapy, and toxicology}}</ref><ref>SMZ in [http://gateway.nl ...cal.diabetesjournals.org/cgi/content/full/21/2/95 "Clinical Diabetes: Case Study: A 90-Year-Old Man With Confusion and Night Sweats"], and [http://www.info4

...ef>(Malerba and Ragnoli. Ambroxol in the 21st century: pharmacological and clinical update. Expert Opin Drug Metab Toxicol 2008; 4(8): 1119-1129)</ref>. There ...escribed first in the late 1970s <ref>(Pueschmann S et al. Pharmacological study on the bromhexine-metabolite ambroxol. Pharmakologische Untersuchungen des

...exposing sufferers to pollen in a controlled, indoor environment. Neither study was able to distinguish between the effects of phenylephrine or a placebo.<

...>{{cite web |url=http://www.clinicaltrials.gov/ct2/show/NCT00656357 |title=Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers

Image = Clinical thermometer 38.7.JPG | ...nfections.<ref>{{cite book |title=Rosen's emergency medicine: concepts and clinical practice |last=Marx |first=John |authorlink= |coauthors= |year=2006 |publis

...ng which will ultimately lead to an effective safety culture. A 1998 NIOSH study concluded that the role of training in developing and maintaining effective ...medical field due to its ability to prevent the spread of diseases. Every clinical facility on US land, civilian or military is governed by OSHA's directives.

...zo L |title=Carbon monoxide cardiotoxicity |journal=Journal of Toxicology. Clinical Toxicology |volume=39 |issue=1 |pages=35–44 |year=2001 |pmid=11327225 |do ...Mehta N|title=Twenty-nine years after carbon monoxide intoxication|journal=Clinical Neurology and Neurosurgery|year=2001|pages=92–95|volume=103|issue=2|pmid=

...some, like [[leukemia]], do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is [[oncology]]. ...N |title=The global smoking epidemic: a history and status report |journal=Clinical lung cancer |volume=5 |issue=6 |pages=371–6 |year=2004 |month=May |doi=10

...broad array of conditions, including [[psychological disorders]] (e.g., [[Clinical depression|depression]], [[anxiety]], [[post-traumatic stress disorder]]) ...cing stress at work also show excessive health care utilization. In a 1998 study of 46,000 workers, health care costs were nearly 50% greater for workers re

...-100102427|title =Manganese|year =1999|author =Barceloux, Donald|journal = Clinical Toxicology|volume =37|page=293|last2 =Barceloux|first2 =Donald}}</ref> ==Clinical toxicity==

...brary.cqpress.com/cqresearcher/cqresrre1995080400.]. According to a recent study for the [[Center for Work-Life Policy]], 1.7 million people consider their ...res are "self-inflicted", they state that it is taking a toll on them. The study shows that seventy percent of US respondents and eighty-one percent of glob

...of exposed workers eventually showing seroconversion and 22 to 31% showing clinical Hepatitis B infection.<ref name = cdc1>Centers for Disease Control and Prev ...iesielski, P.U. Srivastava, R. Marcus, D. Abiteboul et al., A case-control study of HIV seroconversion in health-care workers after percutaneous exposure. N

...stem for Occupational Risks (SENSOR)-Pesticides''' is a U.S. state-based [[Clinical surveillance|surveillance]] program that monitors [[pesticide]]-related ill ...s is not innocuous and that there are better ways to use pesticides," said study co-author Dr. Geoffrey Calvert.<ref name=USAToday/> Officials in organizat

...structures that contained multiple double bonds or multiple rings, but the study of aromatic compounds was in its very early years, and too little evidence ...st1=DL|year=1994|pages=1401–4|issue=7 Pt 2|last2=Bonin|volume=40|journal=Clinical chemistry|first2=MA|last3=Cardinali|first3=FL|last4=McCraw|first4=JM|last5=

...rticle/521338_6 |title=The Role of Toxins in the Changing Epidemiology and Clinical Presentation of Staphylococcal Pneumonia ==Clinical effects==

...id gland producing a lot of noise.<ref>{{cite journal|journal = Journal of Clinical Cancer|year = 2008|volume = 14|pages =1377–1385|doi = 10.1158/1078-0432.C ...0 [[Concentration#.22Parts-per.22 notation|parts per billion]]. However, a study of cancer rates in Taiwan<ref>{{cite journal |doi=10.1289/ehp.8704 |journal

...e.de/books?id=b1ICltm2IdAC --><ref>{{cite journal|title = A Conformational Study of Collagen as Affected by Tanning Procedures|first = E. M.|last = Brown|jo ...urnal |title = Chromium |first = Donald G. |last = Barceloux |journal = Clinical Toxicology |volume = 37 |issue = 2 |pages = 173–194 |year = 1999 |doi =

...easley DM |title=Nicotinic plant poisoning |journal=[[Clinical Toxicology| Clinical Toxicology (Philadelphia, Pa.)]] |volume=47 |issue=8 |pages=771–81 |year ...of a season (this wide variation probably being due to differences between study methodologies as well as a range of working conditions). The long-term heal

...am; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. ISBN 0721629210. {{Rp|859}}</ref> A b ...eruricemia and gout among middle aged and elderly men: the normative aging study |journal=J. Rheumatol. |volume=27 |issue=7 |pages=1708–12 |year=2000 |mon

...1|title = Lead and Zinc Statistics|publisher = International Lead and Zinc Study Group|accessdate = 2009-02-19}}</ref> ...velopment|last = Schoeters|first = G.|coauthors = et al.|journal = Basic & Clinical Pharmacology & Toxicology|volume = 102|pages = 168–175|year = 2008|pmid=1

...and allergies. The problem was that the patient portal had not transferred clinical data, it had transferred insurance billing codes. ...search on breast cancer patient needs and preferences of an Internet-based clinical trial matching system |journal=J Med Internet Res. |volume=9 |issue=2 |page

...ontainer holding information about the patient, and a tool for aggregating clinical date for secondary uses (billing, audit ''etc.''). However, other research ...of a shared electronic summary care record in England: A mixed-method case study. BMJ, 340, c3111</ref>).

In 2008 the corporation Destiny Pharma reported successful clinical trials of an intra-nasally applied porphyrin XF-73 against methicillin-resi The field of [[organic geochemistry]], the study of the impacts and processes that organisms have had on the Earth, had its

...ffeine: assessment of segmental sodium reabsorption in humans. | journal = Clinical Science | volume = 103 | year = 2002 | issue = 5 | accessdate = 2010-06-18 ...TA on coronary arteries is currently (2008) proceeding.<ref name="clinical study">http://www.clinicaltrials.gov/ct/show/NCT00044213?order=2</ref> EDTA pla

protoncsere-reakciók kinetikájának NMR-vizsgálata (NMR study of the proton exchange process in aqueous ...l|last=Lundeen|first=M.|coauthors=Hugus,Z.Z|date=1992|title=A calorimetric study of some metal ion complexing equilibria |journal=Thermochim. Acta|volume=19

...he similar properties it shares with many other VOCs. To be specific, this study analyses the influence of the water solubility of Hb on the partitioning co ...007-11-10 | work = Lab Tests Online | publisher = American Association for Clinical Chemistry | pages = | language = | archiveurl = | archivedate = | quote = |

...l breast tissue excision and radiation therapy. Because of this change in clinical practice lymphedema is now a rarity following breast cancer treatment - and ...kstein, R. S. Benjamin and A. M. Evens. An open-label multicenter phase II study of bevacizumab for the treatment of angiosarcoma. Northwestern University,

...assessments such as bioimpedance, MRI, or CT to build on the findings of a clinical assessment (physical evaluation). From this, results of therapy can be acc ...|pmid=12436430 |doi=10.1002/cncr.10976}}.</ref> However, while there is no clinical evidence to support this belief some therapists have begun to raise concern

...of atherosclerotic embolization originating in the aorta and retrospective study of 64 cases |journal=Acta Clin Belg |volume=51 |issue=6 |pages=395–402 |y ...e journal |author=Nores M, Phillips EH, Morgenstern L, Hiatt JR |title=The clinical spectrum of splenic infarction |journal=Am Surg |volume=64 |issue=2 |pages=

==Clinical significance== The study of lymphatic drainage of various organs is important in diagnosis, prognosi

...r from breast cancer treatment-related lymphedema: a randomized controlled study |journal=Supportive Care in Cancer |volume=18 |issue=3 |pages=383–92 |yea ...ournal |author=Moore E, Gerner RE, Minowada J, Mizrahi J, Woods LK |title=[Clinical experiences with lymphotherapy] |language=Italian |journal=Giornale Di Clin

...to the central role of the [[immune response]] it is wise to approach the study of it with some humility in the face of the task, although there are genera *LAK cells (Lymphokine-activated killer) are a laboratory/clinical subset of NK Cells promoted by [[IL-2]] to attack tumor cells.<ref>''Immuno

...ef><ref>{{cite journal |author=Burt RK, Loh Y, Pearce W, ''et al.'' |title=Clinical applications of blood-derived and marrow-derived stem cells for nonmalignan ...Elevated levels of [[bilirubin]], [[hepatomegaly]] and fluid retention are clinical hallmarks of this condition. There is now a greater appreciation of the gen

...nsitivity,<ref>{{cite journal |author=Montgomery PS, Gardner AW,|title=The clinical utility of a six-minute walk test in peripheral arterial occlusive disease ...drome and conventional cardiovascular risk factors in the Edinburgh Artery Study |journal=Diabetes Care |volume=29 |issue=3 |pages=637–42 |year=2006 |mont

...been developed to assess chronic venous ulcers. It is based on the CEAP (clinical, etiology, anatomy, and pathophysiology) classification system developed by ...8 |year=2004 |pmid=15223495 |doi=10.1016/S0002-9610(03)00284-8}}</ref> one study found that up to 48% of venous ulcers had recurred by the fifth year after

...ry trunk (truncus arteriosus communis) and its embryologic implications. A study of 57 necropsy cases |journal=Am. J. Cardiol. |volume=16 |issue=3 |pages=40 ==Clinical manifestations==

...e posterior longitudinal ligament. An anatomical, radiologic, and clinical study | journal = Clinical Colorectal Cancer

...insufficiency in multiple sclerosis. Correlation of symptoms at onset and clinical course. |journal=Int Angiol |volume=29 |issue=2 |pages=183–8 |year=2010 | ...controls.<ref name="Annals2">{{cite doi|10.1002/ana.22132}}</ref> Another study failed to replicate the abnormalities found by Zamboni.<ref name="pmid20695

Today biochemical and clinical research continues into the role of ADMA in [[cardiovascular disease]], [[d ...levels can be manipulated and, more importantly, if this results in useful clinical benefits.

==Clinical significance== ...y blood pressure: a double-blind, randomised, placebo-controlled phase IIa study|publisher=The Lancet|volume=371|pages=821–827}}</ref>

...Care Med Vol 178. pp 637–643, 2008</ref><ref name=Kawut>Kawut SM et al. Clinical Risk Factors for Portopulmonary Hypertension. Hepatology 2008;48</ref> Typi ...rognostic index has achieved a consensus according to a recent multicenter study: 45% of patients with PPH were denied OLT candidacy based on the degree of

...sdate = 2008-05-02}}</ref> However interim results from the phase IIb/III clinical trial where the drug did not meet the primary efficacy goal has led to the

...lation on pain and β-endorphin blood levels: An active placebo-controlled study. Am J Phys Med Rehabil 2003;82:81-85.].</ref> TCES can be used on people wi ...with the acute application of H-wave stimulation may also be obtained in a clinical situation. Local vasodilation would result in improved perfusion of injured

...10 June 2010.</ref><ref>Mooney, V. "A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for interbody lumbar fusio The use of magnetic field therapy in clinical applications dates back over 500 years. In the 15th century, Swiss physicia

...in Methamphetamine Cravings in Randomized Double-Blind Placebo Controlled Study]</ref> ...5664741 Add-on gabapentin in the treatment of opiate withdrawal]</ref> One study also demonstrates a significant reduction in the severity of [[benzodiazepi

...edical science monitor : international medical journal of experimental and clinical research | volume = 12 | issue = 10 | pages = RA207–19 | year = 2006 | mo ...sychological tests before and after a two-hour run. Data received from the study showed endorphins were produced during the exercise and were attaching them

...1=Klawe|first1=C|last2=Maschke|first2=M|title=Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compo ...e of cannabis derivatives is currently illegal in many countries. A recent study finds that inhaled cannabis is effective in alleviating neuropathy and pain

While one study of Thai users reported that it is sedative in low doses changing over to st ...that mitragynine could be used as an active placebo for comparison in the study. Acting Deputy Director of the NIDA Charles Grudzinskas rejected the propos

...restless legs syndrome with gabapentin enacarbil: a randomized controlled study |journal=Mayo Clinic Proceedings. Mayo Clinic |volume=85 |issue=6 |pages=51 ...about gabapentin itself in the past, but were felt to be outweighed by its clinical utility as an anticonvulsant, whereas the treatment of restless legs syndro

==Clinical trials== The main settings that have seen published clinical trials of nabilone include movement disorders such as [[Parkinson's syndrom

| title =A comparative study on some chemical and biological characteristics of various samples of canna A 2008 study published in the [[British Journal of Psychiatry]] showed significant diffe

...ade D, Robson P, House H, Makela P, Aram J |title=A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable *[http://www.spraytrial.com/ Sativex Cancer Pain Study]

...cite web |url=http://clinicaltrials.gov/ct2/show/NCT00965809 |title=Add on Study on Δ9-THC Treatment for Posttraumatic Stress Disorders (PTSD) - Full Text ...ol reduced tics with no significant adverse effects. A six-week controlled study on 24 patients showed that the patients taking [[dronabinol]] had a signifi

...tz NL |title=Vaporization as a smokeless cannabis delivery system: a pilot study |journal=Clin Pharmacol Ther. |volume=82 |issue=5 |pages=572–8 |year=2007 A 2004 study published in the [[Journal of Cannabis Therapeutics]] found that compared t

'''Intravenous Marijuana Syndrome''' is a rare distinct short-term clinical syndrome related to the IV injection of boiled [[Cannabis (drug)|cannabis]] ...ith normal care, with an average hospital stay of 9 days. In a controlled study, subjects were injected with [[cannabinoids]], but no adverse effects were

...s Cannabis Delivery System: A Pilot Study|author=DI Abrams, et al.|journal=Clinical Pharmacology and Therapeutics|volume=82|year=2007|url=http://www.maps.org/m ...atching", "Webacco", and "Amsterdam Style"), a practice which at least one study has suggested can lead to unintended nicotine dependence.<ref>[http://www.g

...l differentiation of ''Cannabis sativa'' L.: A morphological and molecular study]. ''Euphytica'' '''140'''(1-2): 95-106. Retrieved on 25 February 2007</ref> ...e = "winek1977">Winek, C. L. 1977. Some historical aspects of marijuana. ''Clinical Toxicology'' '''10'''(2): 243-253.</ref>

...tention and verbal working memory performance <ref name=Padula2007/>. In a study by Harvey et al. in 2007, it was found that adolescent regular marijuana us ...crepancy was not as pronounced for non-marijuana users. The result of this study brings an important characteristic of marijuana users to light—specifical

...symptoms during withdrawal from chronic marijuana use. ''Experimental and Clinical Psychopharmacology'' 8(4): 483–492.</ref> According to Budney et al., the

...s: Basic findings from the National Comorbidity Survey. ''Experimental and Clinical Psychopharmacology'' 2, 244-268.</ref> but there is plenty of documented ev ...an cause withdrawal symptoms as severe as those from quitting tobacco. The study of 12 adults who were heavy users of both cannabis and cigarettes, found th

A study published in the ''[[South African Journal of Science]]'' showed that "pipe A [[research|scientific study]] published in 2000 in the Journal of Forensic Sciences (JFS) found that th

...Murray |editor1-first=Peter |editor1-last=Scally |title=Oxford Handbook of Clinical Specialties |edition=6 |date= |year=2003 |publisher=Oxford University Press ...ba | first1 = Michelle B. | last2 = Ravindranath | first2 = Divy | title = Clinical manual of emergency psychiatr | url = http://books.google.co.uk/books?id=l8

...ane|membrane]]s that surround all [[cell (biology)|biological cell]]s. The study of ion channels involves many scientific techniques such as [[voltage clamp ...Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote

...ioid abusers. Psychopharmacology (Berl). 2000 Mar;148(4):374-83.</ref><ref>Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addictio ...use of alcohol with any opioid increases the risk of overdose. One French study showed a higher incidence of fatal overdose in patients who injected both b

...ilymed.nlm.nih.gov |date= |accessdate=2010-07-28}}</ref> which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 196 ...inicaltrials.gov/ct2/show/NCT00538863 |title=Long Term Safety and Efficacy Study of Fentanyl Sublingual Spray for the Treatment of Breakthrough Cancer Pain

...of methadone: implications for the treatment of opioid dependence |journal=Clinical pharmacokinetics |volume=41 |issue=14 |pages=1153–93 |year=2002 |pmid=124 ...rashes than non-abuse patients in a study by Queensland University. In the study of a group of 220 drug abuse patients, most of them poly-drug abusers, 17 w

...holine]]<ref>.[[#refCapasso2006|Capasso 2006]].</ref> Results from a small study by an assistant professor at the University of Iowa indicate that it may ha Clinical pharmacologist John Mendelsohn has also said:

...plied that the compound was first found to have clinical potential in this study<ref>[http://www.dod.mil/pubs/foi/02-A-0846RELEASE.pdf ''Memorandum for the ...rooks DE | title = Dextromethorphan-induced serotonin syndrome | journal = Clinical Toxicology (Philadelphia, Pa.) | volume = 46 | issue = 8 | pages = 771–3

...gastrointestinal and operative site bleeding: a postmarketing surveillance study ''JAMA'' 1996; '''275''':376-82</ref> indicated a dose-response relationshi ...commended for [[Obstetrics|obstetric]] analgesia because it has not been [[Clinical trial|adequately tested]] for obstetrical administration and has demonstrab

...9 | year=2006 | pmid=16645966 | doi=10.1002/art.21887}}</ref> A very large study of 1,028,437 Danish users of various NSAIDs or coxibs, published online on ...dically in patients receiving long-term therapy with diclofenac. Based on clinical trial data and postmarketing experiences, transaminases should be monitored

| first11 = S (the International Melissa Study Group) ...edica.com/product_sites/METACAMINCats/documents/Metacam_Inj_cats_label.pdf clinical dosing instructions for cats.]</ref> In June 2007, a new oral version of M

...or = Kantor, T. G. | title = Ketoprofen: a review of its pharmacologic and clinical properties | journal = Pharmacotherapy | year = 1986 |volume=6 | issue=3 |p ...he treatment of tendinitis: a randomized, double blind, placebo controlled study. | volume = 32 | issue = 8 | pages = 1563–70 | journal = The Journal of r

...;mg per day a level of injury lower than that of other NSAIDs; however, in clinical practice meloxicam can still cause some [[Peptic ulcer|ulcer]] complication ...9% of NSAID expenditures were for COX-2 inhibitors. Over the period of the study, COX-2 inhibitors rose from 10.03% of total NSAIDs prescribed by specialty

...salate to prevent or treat type II diabetes: "In a 20-patient, month-long study, the fasting glucose levels of those who took salsalate declined 13% compar ..._led_by_joslin_scientists.htm Generic Drug for Type 2 Diabetes Passes Next Clinical Hurdle]</ref>

...name="former29">David MA, Eric GH. Antipyretics: mechanisms of action and clinical use in fever suppresion. AJ of Medicine [internet]. 2001 Sep [cited 2010 Ja ...ve similar characteristics and tolerability. There is little difference in clinical efficacy among the NSAIDs when used at equivalent doses. Rather, difference

...e dose of etomidate for rapid sequence induction: a prospective randomized study." J Trauma 65(3): 573-9. ...echula, R. T. Sweis and E. B. Kulstad (2009). "A prospective observational study of the effect of etomidate on septic patient mortality and length of stay."

.... (1989) Inhalation Anesthesia (Chapter 11). In P. G. Barash et al. (Eds.) Clinical Anesthesia. Philadelphia, PA: Lippincott.</ref> ...mination in groundwater, and the effects observed in laboratory animals. A study published in August 2008, has demonstrated effects of TCE on human mitochon

|title=Xenon: elemental anaesthesia in clinical practice |title=An Introduction to the Study of Spectrum Analysis

...cal setting as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and [[alcoholism]], and to improve athletic perform ...lular events induced by gamma-hydroxybutyrate in striatum: a microdialysis study |journal=[[J. Neurochem.]] |volume=56 |issue=3 |pages=938–44 |year=1991 |

The exact composition of mafeisan, similar to all of Hua Tuo's clinical knowledge, was lost when he burned his manuscripts, just before his death.< ...me formulation based on historical records but none have achieved the same clinical efficacy as Hua Tuo's. In any event, Hua Tuo's formula did not appear to be

...rried by his poor social development that she considered entering him in a study for [[Asperger syndrome|autistic]] children led by [[Bruno Bettelheim]].<re ...ional instability and dislike of mind control to his participation in this study. <ref name="making">{{cite web|url=http://www.theatlantic.com/issues/2000/0

...ontrol following the attacks, he is also the lead author of a study of the clinical and immunologic responses to anthrax exposure.<ref>[http://www.fairfield.ed Martin is currently the director of the Infectious Disease Clinical Research Program (IDCRP) at the [[Uniformed Services University]] (USU). P

...), lungs ('''inhalation'''), or skin ('''cutaneous''') and causes distinct clinical symptoms based on its site of entry. An infected human will generally be qu ...ax from community-acquired pneumonia using chest radiograph findings and a clinical algorithm. Chest. 2007 Feb;131(2):489-96.</ref> Illness progressing to the

...The researchers are preparing to conduct further research, including human clinical trials.<ref>AFNS. [http://www.ales.ualberta.ca/afns/news.cfm?story=75846 Al

...ilk]] began to be widely commercially available at low prices, and several clinical studies suggested that babies fed evaporated milk formula thrive as well as | title = An experimental study of the use of unsweetened evaporated milk for the preparation of infant fee

...en-free, casein-free diet in autism: results of a preliminary double blind clinical trial |journal=J Autism Dev Disord |volume=36 |issue=3 |pages=413–20 |yea ....; Colin T., PH D. Campbell |title=The China study: the most comprehensive study of nutrition ever conducted and the startling implications for diet, weight

...ilk]] began to be widely commercially available at low prices, and several clinical studies from that time period suggested that babies fed evaporated milk for | title = An experimental study of the use of unsweetened evaporated milk for the preparation of infant fee

...ame=pj>The [[Pharmaceutical Journal]], Vol 264 No 7078 p48 January 8, 2000 Clinical.</ref> Several mechanisms for this protection have been proposed: ...ite web|url=http://www.britishcheese.com/news.cfm?page_id=240 |title=Sleep Study, 2005 |publisher=Britishcheese.com |date= |accessdate=2010-05-01}}</ref> Ch

.../> An early account of a European encounter with yoghurt occurs in French clinical history: [[Francis I of France|Francis I]] suffered from a severe [[diarrho A study published in the ''[[International Journal of Obesity]]'' (11 January 2005)

...sclerosis in inbred strains of mice |journal=The Journal of Laboratory and Clinical Medicine |volume=112 |issue=1 |pages=36–42 |year=1988 |month=July |pmid=3 ...es dietary linolenic acid influence blood pressure?" ''American Journal of Clinical Nutrition''. 44: 336-340.