Salsalate
File:Salsalate.svg | |
Systematic (IUPAC) name | |
---|---|
2-(2-Hydroxybenzoyl)oxybenzoic acid | |
Identifiers | |
CAS Number | 552-94-3 |
ATC code | N02BA06 (WHO) |
PubChem | CID 5161 |
DrugBank | DB01399 |
Chemical data | |
Formula | C14H10O5 |
Molar mass | 258.23 g/mol[[Script error: No such module "String".]] |
(verify) |
Salsalate is a non-steroidal anti-inflammatory drug (NSAID). Salsalate is in a class of drugs called salicylates. Salsalate may work by inhibiting the production of and release of prostaglandins. Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.[1]
Typical Use
Salsalate is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions. Salsalate is also recommended by physicians as an anti-inflamatory alternative to naproxen, and ibuprofen for patients that have had minor stomach bleeding or stomach upset. It has also been used as an alternative to narcotic pain medicine for people with spinal disc protrusion.
"In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo." [2]
Research on use to prevent or treat Type II Diabetes
The Wall Street Journal Health Blog reported on research on using Salsalate to prevent or treat type II diabetes: "In a 20-patient, month-long study, the fasting glucose levels of those who took salsalate declined 13% compared with those who took a placebo. The results, published in the Feb. issue of Diabetes Care, suggest that the drug reduces blood sugar in obese adults who don’t have diabetes, apparently by making insulin work better."[3]
On March 20th, 2010, The Joslin Diabetes Center , Boston, MA, released a report entitled: Generic Drug for Type 2 Diabetes Passes Next Clinical Hurdle - "Salsalate, an anti-inflammatory agent, shows encouraging results in preliminary trial"[4]
References
Cite error: Invalid <references>
tag;
parameter "group" is allowed only.
<references />
, or <references group="..." />
- ↑ drugs.com Salsalate entry [1]
- ↑ DrugBank: DB01399 (Salsalate)
- ↑ Aspirin cousin could help prevent diabetes blogs.wsj.com
- ↑ Generic Drug for Type 2 Diabetes Passes Next Clinical Hurdle
- Pages with script errors
- Pages with broken file links
- Infobox drug tracked parameters
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- 2Fix
- Non-steroidal anti-inflammatory drugs
- Salicylates