Search results

...Nivorozhkin A, Szabó C | title = Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol | journal = ...bition of [[amidophosphoribosyl transferase]], the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid form

...in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors.| journal = Parasitol Research | volume = 100 | issue = 4 | pages = 671–6 ...[[phospholipase A]], antigen presentation in dendritic cells, release of [[enzyme]]s from [[lysosome]]s, release of [[reactive oxygen species]] from [[macrop

...acists |title=Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. Insights from the Society of Infectious Diseases Phar ...]s, [[polyarthritis]], [[jaundice]], [[elevated transaminases|raised liver enzyme levels]], and/or [[hepatotoxicity]].<ref name=Rossi/>

...or = Neu HC, Gootz TD | chapter = Antimicrobial Chemotherapy:Antimicrobial Inhibitors of Ribosome Function | title = Baron's Medical Microbiology |editor=Baron ...noted for its cause of "Gray Baby Syndrome" because of infants lack of the enzyme glucoronyl transferase which is the main pathway conjugational excretion, w

Neonates (babies up to the age of one month) have immature enzyme systems in their [[erythrocyte|red blood cell]]s ([[glutathione]] instabili {{Nucleic acid inhibitors}}

| class1 = [[Dihydrofolate reductase]] [[enzyme inhibitor|inhibitor]] (16.7%) ...minobenzoic acid]] (PABA) and, thus, are [[competitive inhibitor]]s of the enzyme, inhibiting the production of [[dihydropteroic acid]].

...d are thus dependent on their own ''de novo'' synthesis. Inhibition of the enzyme starves the bacteria of nucleotides necessary for [[DNA replication]]. ...p://www.med.sc.edu:96/Biopharm/PDFs/NucleicAcidInhibitors.pdf Nucleic acid inhibitors] (PDF file).

...ase activity by promoting the formation of an inactive intermediate of the enzyme, thus preventing the conversion of hydrogen peroxide to hypochlorous acid, {{Nucleic acid inhibitors}}

Rifampicin is an effective liver enzyme-inducer, promoting the upregulation of [[hepatic]] [[cytochrome P450]] enzy ...pamil]], [[nifedipine]], [[simvastatin]], [[midazolam]] and [[HIV protease inhibitors]]. Other possible interactions include [[antiretroviral agents]], [[everoli

...nosine]] (a [[purine]]). Its target is the viral [[reverse transcriptase]] enzyme. ...nosine]] and [[zalcitabine]]. HIV strains that are resistant to [[protease inhibitors]] are not likely to be resistant to abacavir.

...[[cytidine]]. The drug works by inhibiting [[reverse transcriptase]], the enzyme that copies HIV RNA into new viral DNA. By interfering with this process, w [[Category:Nucleoside analog reverse transcriptase inhibitors]]

...approval process switched to [[protease inhibitor (pharmacology)|protease inhibitors]]. According to the manufacturer's 2004 annual report, its patent will expi ...r incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a

...nscriptase inhibitor]]s (nRTIs), which block [[reverse transcriptase]], an enzyme crucial to viral production in [[HIV]]-infected people. [[Category:Nucleoside analog reverse transcriptase inhibitors]]

...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs act allosterically by binding to a distinct site away ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors | journal=Proc Natl Acad Sci USA | volume=99 | pages=14410–15 | pmid=1238

...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors |journal=Proc Natl Acad Sci USA. |volume=99 |issue=22 |pages=14410–5 |yea

...n, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of these latter drug ...cture inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors.

...zes saquinavir to an inactive form, but with the ritonavir inhibiting this enzyme, the saquinavir blood plasma levels increased considerably. Additionally, r Unlike other protease inhibitors, the absorption of saquinavir seems to be improved by [[omeprazole]].<ref>{

...o the class of drugs known as [[protease inhibitor (pharmacology)|protease inhibitors]] (PIs) and like other PIs is generally used in combination with other anti ...being widely prescribed in combination with [[HIV]] reverse transcriptase inhibitors for the treatment of HIV infection. <ref>{{cite journal |author=Zhang KE, W

Ribavirin 5' mono- di- and tri-phosphates, in addition, are all inhibitors of certain viral RNA-dependent RNA polymerases which are a feature of anti- ...peutic ribavirin concentrations. Any difference between cellular and viral enzyme handling of ribavirin-containin mRNA transcripts is a potential mechanism o

...dale RF, Sellers EM, Romach MK |title=Treatment of codeine dependence with inhibitors of cytochrome P450 2D6 |journal=J Clin Psychopharmacol |volume=22 |issue=3 ...o morphine occurs in the liver and is catalysed by the [[cytochrome P450]] enzyme [[CYP2D6]]. [[CYP3A4]] produces norcodeine and [[UGT2B7]] conjugates codein

...arbocations that react with biological [[nucleophile]]s (such as DNA or an enzyme) in the cell. [[Category:Corrosion inhibitors]]

...=PDF|quote=Although the current quinolones are not considered to be potent inhibitors of eucaryotic topoisomerases, some effects on these and other enzymes invol ...comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase |journal=Adv Exp Med Biol. |volume=390 |pages=59–69 |year=1

...[serotonin syndrome]], if combined with any [[selective serotonin reuptake inhibitors]] (SSRIs) or other serotonin reuptake inhibitor (e.g., [[duloxetine]], [[si ...monophosphate ([[Cyclic guanosine monophosphate|cGMP]]) by inhibiting the enzyme [[guanylate cyclase]]: this action results in reduced responsiveness of ves

...he United States, trade name ''Glucovance''), the [[dipeptidyl peptidase-4 inhibitors|dipeptidyl peptidase-4 inhibitor]] [[sitagliptin]] (trade name ''Janumet'') .../ref> Metformin activates [[AMP-activated protein kinase]] (AMPK), a liver enzyme that plays an important role in insulin signaling, whole body energy balanc

Valproic acid is an [[Enzyme inhibitor|inhibitor]] of the [[enzyme]] [[histone deacetylase 1]] (HDAC1), hence it is a [[histone deacetylase in ...ally as often as once a week and then once every 2 months. Temporary liver enzyme increase has been reported in 20% of cases during the first few months of t

...A, Wong DT |title=A note on the discovery of selective serotonin reuptake inhibitors |journal=Life Sci |volume=61 |issue=12 |pages=1203 |year=1997 |pmid=9315511 ...ey CF |title=Extrapyramidal reactions and the selective serotonin-reuptake inhibitors |journal=Ann Pharmacother |volume=31 |issue=12 |pages=1481–9 |year=1997 |

...es, although they all have similar effects and most have inhibition of the enzyme [[cyclooxygenase]] as their [[nonsteroidal anti-inflammatory drugs#Mechanis ...er NSAIDs (such as [[diclofenac]] and [[ibuprofen]]), which are reversible inhibitors.

Proton pump inhibitors may be associated with a greater risk of hip fractures,<ref name="JAMA">{{c | title=Use of proton pump inhibitors and risk of osteoporosis-related fractures

...r of the group of ACE inhibitors known as the dicarboxylate-containing ACE inhibitors. ...hich aided in the development of subsequent [[carboxylate]]-containing ACE inhibitors.

...st by the hydroxylation of the amino acid [[L-tyrosine]] to L-DOPA via the enzyme tyrosine 3-monooxygenase, also known as [[tyrosine hydroxylase]], and then ...rboxylase|dopa decarboxylase]]), such as [[carbidopa]] or [[benserazide]]. Inhibitors of alternative metabolic route for dopamine by [[catechol-O-methyl transfer

...tory drugs such as ibuprofen work by [[enzyme inhibitor|inhibiting]] the [[enzyme]] [[cyclooxygenase]] (COX), which converts [[arachidonic acid]] to [[Prosta ...hor=Kakuta H, Zheng X, Oda H, ''et al.'' |title=Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage.

...on the viral enzyme [[reverse transcriptase]]. Reverse transcriptase is an enzyme that retroviruses, including HIV, utilize to replicate themselves. Scientis ...urnal | author=De Clercq E | title=HIV resistance to reverse transcriptase inhibitors. | journal=Biochem Pharmacol | volume=47 | issue=2 | pages=155–69 | year=

...|title=The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiat ...i=10.1002/med.20035}}</ref> via [[glucuronidation]] by phase II metabolism enzyme [[UGT2B7|UDP-glucuronosyl transferase-2B7]] (UGT2B7). About 60% of morphine

...as [[glucuronidation]] in the [[liver]] as part of the [[cytochrome P450]] enzyme system. Diazepam has several pharmacologically [[active metabolites]]. The Diazepam does not increase or decrease hepatic enzyme activity, and does not alter the metabolism of other compounds. There is no

...n is being replaced by newer drugs including angiotensin-converting enzyme inhibitors, and the calcium channel blocking agents. As new pharmacotherapeutic agents

'''Cilazapril''' is a [[pyridazine]] [[angiotensin-converting enzyme]] inhibitor ([[ACE inhibitor]]) used for the treatment of [[hypertension]] {{ACE inhibitors}}

...'lye-SIN-o-pril'') is a drug of the [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]] class that is primarily used in treatment of [[hypertensi ...> Lisinopril has a number of properties that distinguish it from other ACE inhibitors: it is [[Hydrophile|hydrophilic]], has long [[half-life]] and tissue penetr

'''Gemopatrilat''' is a drug which acts as an [[vasopeptidase]] [[enzyme inhibitor|inhibitor]].<ref name="pmid12472769">{{cite journal |author=Laver {{ACE inhibitors}}

'''Renin inhibitor''', or inhibitors of [[renin]], are a new group of [[pharmaceutical]]s that are used primaril ...me="ref 1"> [http://pharmaxchange.info/presentations/dri.html Direct Renin Inhibitors Presentation]</ref>

...xhibit mucoadhesive, permeation enhancing, controlled release as well as [[enzyme]] and [[efflux pump]] inhibitory properties. These features make the thiome ...chnürch A. In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials 2006;27(34):5855-60.

...iomer]] of octopamine is by β-[[hydroxylation]] of [[tyramine]] via the [[enzyme]] [[dopamine β-hydroxylase]]. Under the trade names '''Epirenor''', '''Nor

...hibitor]] of [[Dopamine beta hydroxylase|dopamine beta-hydroxylase]], an [[enzyme]] that catalyzes the conversion of [[dopamine]] to [[norepinephrine]].<ref> {{Enzyme inhibition}}

...d, follow-up of exposed individuals includes counseling and HIV testing by enzyme immunoassay to monitor for a possible seroconversion for at least 6 months

...volume = 1 | pages = 231–238 | pmid = 13892106}}</ref> Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic act ...nd the oxidised form is light-blue. Ferroin is used as a cell permeable [[Enzyme inhibitor|inhibitor]] for [[metalloprotease]]s in cell biology.

...biology]], ion depletion is commonly used to deactivate metal-dependent [[enzyme]]s, either as an assay for their reactivity or to suppress damage to DNA or * The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/smi_summary?mid=J00149 EDTA]

...iron will remain oxidized and incapable to bind oxygen. In such cases, the enzyme [[cytochrome b5 reductase|methemoglobin reductase]] will be able to eventua ...nner, hemoglobin ligands also include [[competitive inhibition|competitive inhibitors]] such as [[carbon monoxide]] (CO) and [[allosteric regulation|allosteric]]

...emoval of two C-terminal residues by the enzyme ''[[angiotensin-converting enzyme]]'' (ACE, or ''kinase''), which is found predominantly in the [[capillary|c * The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.953 I04.953]

...s [[macula densa]] decreases, then the juxtaglomerular cells release the [[enzyme]] [[renin]]. ...onverted to ''[[angiotensin|angiotensin II]]'' by [[angiotensin-converting enzyme]] (ACE)<ref>{{cite journal |author=Paul M, Poyan Mehr A, Kreutz R |title=Ph

...xed-function oxidases, mainly [[CYP 2C9]]. Thus supplementing with CYP 2C9 inhibitors leads to extended intoxication. Cannabinoid production starts when an [[enzyme]] causes [[geranyl pyrophosphate]] and [[Olivetol|olivetolic acid]] to comb

...erisation|isomerised]] to L-methylmalonyl-CoA. A [[vitamin B12]]-dependent enzyme catalyzes rearrangement of L-methylmalonyl-CoA to [[succinyl-CoA]], which i ...pionyl-CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Propanoate is metabolized oxidatively by glia, which suggests astrocytic

===COX-2 inhibitors=== ...enzyme. The COX2 inhibitors were thus developed to inhibit only the COX2 enzyme (traditional NSAIDs block both versions in general). These drugs (such as

...omorphone when processing [[hydrocodone]] using the cytochrome p450 II-D-6 enzyme pathway ([[CYP2D6]]). This is the same route that is used to convert many d

...ol, it can intensify drowsiness. It may interact with [[monoamine oxidase inhibitors]], as well as other drugs that cause drowsiness. It is in [[Food and Drug ...ref name="Davis, Mellar P. 2005 59–68"/> The hepatic [[cytochrome P450]] enzyme [[CYP2D6]] converts it into [[hydromorphone]], a more potent opioid. CYP2D6

...16051647">{{cite journal | author = Gillman PK | title = Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | journal = British Journal of An ...active metabolite [[dextrorphan]] in the liver by the [[cytochrome P450]] enzyme [[CYP2D6]]. The average dosage necessary for effective antitussive therapy

Tramadol is demethylated by the liver enzyme [[CYP2D6]]<ref>{{cite pmid|14624403}}</ref> in the same way as codeine, and ...oth (+) and (-)-''O''-desmethyltramadol are inactive as serotonin reuptake inhibitors,<ref>{{cite pmid|9389855}}</ref> but (-)-''O''-desmethyltramadol retains ac

...the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes [[Prostaglandin|prostaglandins]] (cyclooxygenase), resulting in

...dal anti-inflammatory drug]] (NSAID) that directly targets [[COX-2]], an [[enzyme]] responsible for [[inflammation]] and [[pain]]. Selectivity for COX-2 redu {{details|Discovery and development of cyclooxygenase 2 inhibitors}}

Most NSAIDs act as nonselective inhibitors of the [[enzyme]] [[cyclooxygenase]] (COX), inhibiting both the cyclooxygenase-1 (COX-1) an ..._2/b3540?view=long&pmid=19797346</ref> Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis (PGE2)

...xylate_oxidase|ACC-oxidase]] (ACO), formerly known as the Ethylene Forming Enzyme (EFE). Ethylene biosynthesis can be induced by endogenous or exogenous ethy ...don't respond to ethylene produced endogenously or from exogenous sources. Inhibitors of ethylene perception include compounds that have a similar shape to ethyl

...Peptides Isolated from It That are Inhibitors to Angiotensin I-Converting Enzyme