Search results

• Allopurinol
  ...Nivorozhkin A, Szabó C | title = Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol | journal = ...bition of [[amidophosphoribosyl transferase]], the first and rate-limiting enzyme of purine biosynthesis. Allopurinol therefore decreases both uric acid form
  7 KB (864 words) - 16:41, 27 September 2010
• Chloroquine
  ...in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors.| journal = Parasitol Research | volume = 100 | issue = 4 | pages = 671–6 ...[[phospholipase A]], antigen presentation in dendritic cells, release of [[enzyme]]s from [[lysosome]]s, release of [[reactive oxygen species]] from [[macrop
  16 KB (2,187 words) - 16:41, 27 September 2010
• Clindamycin
  ...acists |title=Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. Insights from the Society of Infectious Diseases Phar ...]s, [[polyarthritis]], [[jaundice]], [[elevated transaminases|raised liver enzyme levels]], and/or [[hepatotoxicity]].<ref name=Rossi/>
  25 KB (3,261 words) - 14:17, 11 September 2010
• Chloramphenicol
  ...or = Neu HC, Gootz TD | chapter = Antimicrobial Chemotherapy:Antimicrobial Inhibitors of Ribosome Function | title = Baron's Medical Microbiology |editor=Baron ...noted for its cause of "Gray Baby Syndrome" because of infants lack of the enzyme glucoronyl transferase which is the main pathway conjugational excretion, w
  29 KB (3,876 words) - 16:42, 27 September 2010
• Nitrofurantoin
  Neonates (babies up to the age of one month) have immature enzyme systems in their [[erythrocyte|red blood cell]]s ([[glutathione]] instabili {{Nucleic acid inhibitors}}
  12 KB (1,576 words) - 16:43, 27 September 2010
• Co-trimoxazole
  | class1 = [[Dihydrofolate reductase]] [[enzyme inhibitor|inhibitor]] (16.7%) ...minobenzoic acid]] (PABA) and, thus, are [[competitive inhibitor]]s of the enzyme, inhibiting the production of [[dihydropteroic acid]].
  10 KB (1,346 words) - 16:43, 27 September 2010
• Trimethoprim
  ...d are thus dependent on their own ''de novo'' synthesis. Inhibition of the enzyme starves the bacteria of nucleotides necessary for [[DNA replication]]. ...p://www.med.sc.edu:96/Biopharm/PDFs/NucleicAcidInhibitors.pdf Nucleic acid inhibitors] (PDF file).
  8 KB (1,056 words) - 20:12, 10 September 2010
• Dapsone
  ...ase activity by promoting the formation of an inactive intermediate of the enzyme, thus preventing the conversion of hydrogen peroxide to hypochlorous acid, {{Nucleic acid inhibitors}}
  15 KB (2,087 words) - 16:43, 27 September 2010
• Rifampicin
  Rifampicin is an effective liver enzyme-inducer, promoting the upregulation of [[hepatic]] [[cytochrome P450]] enzy ...pamil]], [[nifedipine]], [[simvastatin]], [[midazolam]] and [[HIV protease inhibitors]]. Other possible interactions include [[antiretroviral agents]], [[everoli
  18 KB (2,471 words) - 16:43, 27 September 2010
• Abacavir
  ...nosine]] (a [[purine]]). Its target is the viral [[reverse transcriptase]] enzyme. ...nosine]] and [[zalcitabine]]. HIV strains that are resistant to [[protease inhibitors]] are not likely to be resistant to abacavir.
  8 KB (1,124 words) - 16:44, 27 September 2010
• Emtricitabine
  ...[[cytidine]]. The drug works by inhibiting [[reverse transcriptase]], the enzyme that copies HIV RNA into new viral DNA. By interfering with this process, w [[Category:Nucleoside analog reverse transcriptase inhibitors]]
  5 KB (667 words) - 16:44, 27 September 2010
• Lamivudine
  ...approval process switched to [[protease inhibitor (pharmacology)|protease inhibitors]]. According to the manufacturer's 2004 annual report, its patent will expi ...r incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a
  9 KB (1,248 words) - 16:44, 27 September 2010
• Tenofovir
  ...nscriptase inhibitor]]s (nRTIs), which block [[reverse transcriptase]], an enzyme crucial to viral production in [[HIV]]-infected people. [[Category:Nucleoside analog reverse transcriptase inhibitors]]
  6 KB (871 words) - 16:45, 27 September 2010
• Efavirenz
  ...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs act allosterically by binding to a distinct site away ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors | journal=Proc Natl Acad Sci USA | volume=99 | pages=14410–15 | pmid=1238
  10 KB (1,441 words) - 16:45, 27 September 2010
• Nevirapine
  ...transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme's active site, NNRTIs bind allosterically at a distinct site away from the ...ase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors |journal=Proc Natl Acad Sci USA. |volume=99 |issue=22 |pages=14410–5 |yea
  15 KB (2,090 words) - 16:45, 27 September 2010
• Ritonavir
  ...n, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of these latter drug ...cture inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors.
  9 KB (1,233 words) - 15:07, 6 July 2010
• Saquinavir
  ...zes saquinavir to an inactive form, but with the ritonavir inhibiting this enzyme, the saquinavir blood plasma levels increased considerably. Additionally, r Unlike other protease inhibitors, the absorption of saquinavir seems to be improved by [[omeprazole]].<ref>{
  5 KB (717 words) - 15:07, 6 July 2010
• Nelfinavir
  ...o the class of drugs known as [[protease inhibitor (pharmacology)|protease inhibitors]] (PIs) and like other PIs is generally used in combination with other anti ...being widely prescribed in combination with [[HIV]] reverse transcriptase inhibitors for the treatment of HIV infection. <ref>{{cite journal |author=Zhang KE, W
  8 KB (1,160 words) - 16:45, 27 September 2010
• Ribavirin
  Ribavirin 5' mono- di- and tri-phosphates, in addition, are all inhibitors of certain viral RNA-dependent RNA polymerases which are a feature of anti- ...peutic ribavirin concentrations. Any difference between cellular and viral enzyme handling of ribavirin-containin mRNA transcripts is a potential mechanism o
  23 KB (3,222 words) - 16:45, 27 September 2010
• Codeine
  ...dale RF, Sellers EM, Romach MK |title=Treatment of codeine dependence with inhibitors of cytochrome P450 2D6 |journal=J Clin Psychopharmacol |volume=22 |issue=3 ...o morphine occurs in the liver and is catalysed by the [[cytochrome P450]] enzyme [[CYP2D6]]. [[CYP3A4]] produces norcodeine and [[UGT2B7]] conjugates codein
  40 KB (5,581 words) - 16:45, 27 September 2010
• Sodium nitrite
  ...arbocations that react with biological [[nucleophile]]s (such as DNA or an enzyme) in the cell. [[Category:Corrosion inhibitors]]
  21 KB (3,046 words) - 16:45, 27 September 2010
• Ciprofloxacin
  ...=PDF|quote=Although the current quinolones are not considered to be potent inhibitors of eucaryotic topoisomerases, some effects on these and other enzymes invol ...comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase |journal=Adv Exp Med Biol. |volume=390 |pages=59–69 |year=1
  88 KB (11,930 words) - 16:46, 27 September 2010
• Methylene blue
  ...[serotonin syndrome]], if combined with any [[selective serotonin reuptake inhibitors]] (SSRIs) or other serotonin reuptake inhibitor (e.g., [[duloxetine]], [[si ...monophosphate ([[Cyclic guanosine monophosphate|cGMP]]) by inhibiting the enzyme [[guanylate cyclase]]: this action results in reduced responsiveness of ves
  27 KB (3,650 words) - 16:46, 27 September 2010
• Metformin
  ...he United States, trade name ''Glucovance''), the [[dipeptidyl peptidase-4 inhibitors|dipeptidyl peptidase-4 inhibitor]] [[sitagliptin]] (trade name ''Janumet'') .../ref> Metformin activates [[AMP-activated protein kinase]] (AMPK), a liver enzyme that plays an important role in insulin signaling, whole body energy balanc
  66 KB (8,976 words) - 16:47, 27 September 2010
• Valproic acid
  Valproic acid is an [[Enzyme inhibitor|inhibitor]] of the [[enzyme]] [[histone deacetylase 1]] (HDAC1), hence it is a [[histone deacetylase in ...ally as often as once a week and then once every 2 months. Temporary liver enzyme increase has been reported in 20% of cases during the first few months of t
  25 KB (3,328 words) - 16:47, 27 September 2010
• Fluoxetine
  ...A, Wong DT |title=A note on the discovery of selective serotonin reuptake inhibitors |journal=Life Sci |volume=61 |issue=12 |pages=1203 |year=1997 |pmid=9315511 ...ey CF |title=Extrapyramidal reactions and the selective serotonin-reuptake inhibitors |journal=Ann Pharmacother |volume=31 |issue=12 |pages=1481–9 |year=1997 |
  52 KB (7,168 words) - 16:47, 27 September 2010
• Aspirin
  ...es, although they all have similar effects and most have inhibition of the enzyme [[cyclooxygenase]] as their [[nonsteroidal anti-inflammatory drugs#Mechanis ...er NSAIDs (such as [[diclofenac]] and [[ibuprofen]]), which are reversible inhibitors.
  78 KB (10,918 words) - 16:52, 27 September 2010
• Omeprazole
  Proton pump inhibitors may be associated with a greater risk of hip fractures,<ref name="JAMA">{{c | title=Use of proton pump inhibitors and risk of osteoporosis-related fractures
  17 KB (2,299 words) - 09:15, 5 September 2010
• Enalapril
  ...r of the group of ACE inhibitors known as the dicarboxylate-containing ACE inhibitors. ...hich aided in the development of subsequent [[carboxylate]]-containing ACE inhibitors.
  5 KB (725 words) - 16:48, 27 September 2010
• Dopamine
  ...st by the hydroxylation of the amino acid [[L-tyrosine]] to L-DOPA via the enzyme tyrosine 3-monooxygenase, also known as [[tyrosine hydroxylase]], and then ...rboxylase|dopa decarboxylase]]), such as [[carbidopa]] or [[benserazide]]. Inhibitors of alternative metabolic route for dopamine by [[catechol-O-methyl transfer
  48 KB (6,470 words) - 16:48, 27 September 2010
• Ibuprofen
  ...tory drugs such as ibuprofen work by [[enzyme inhibitor|inhibiting]] the [[enzyme]] [[cyclooxygenase]] (COX), which converts [[arachidonic acid]] to [[Prosta ...hor=Kakuta H, Zheng X, Oda H, ''et al.'' |title=Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage.
  29 KB (3,955 words) - 22:17, 21 September 2010
• Zidovudine
  ...on the viral enzyme [[reverse transcriptase]]. Reverse transcriptase is an enzyme that retroviruses, including HIV, utilize to replicate themselves. Scientis ...urnal | author=De Clercq E | title=HIV resistance to reverse transcriptase inhibitors. | journal=Biochem Pharmacol | volume=47 | issue=2 | pages=155–69 | year=
  21 KB (3,049 words) - 16:51, 27 September 2010
• Morphine
  ...|title=The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiat ...i=10.1002/med.20035}}</ref> via [[glucuronidation]] by phase II metabolism enzyme [[UGT2B7|UDP-glucuronosyl transferase-2B7]] (UGT2B7). About 60% of morphine
  87 KB (12,376 words) - 16:51, 27 September 2010
• Diazepam
  ...as [[glucuronidation]] in the [[liver]] as part of the [[cytochrome P450]] enzyme system. Diazepam has several pharmacologically [[active metabolites]]. The Diazepam does not increase or decrease hepatic enzyme activity, and does not alter the metabolism of other compounds. There is no
  78 KB (10,295 words) - 16:51, 27 September 2010
• Digitalis lanata
  ...n is being replaced by newer drugs including angiotensin-converting enzyme inhibitors, and the calcium channel blocking agents. As new pharmacotherapeutic agents
  8 KB (1,193 words) - 12:26, 7 July 2010
• Cilazapril
  '''Cilazapril''' is a [[pyridazine]] [[angiotensin-converting enzyme]] inhibitor ([[ACE inhibitor]]) used for the treatment of [[hypertension]] {{ACE inhibitors}}
  2 KB (224 words) - 09:44, 20 September 2010
• Lisinopril
  ...'lye-SIN-o-pril'') is a drug of the [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]] class that is primarily used in treatment of [[hypertensi ...> Lisinopril has a number of properties that distinguish it from other ACE inhibitors: it is [[Hydrophile|hydrophilic]], has long [[half-life]] and tissue penetr
  10 KB (1,316 words) - 09:44, 20 September 2010
• Gemopatrilat
  '''Gemopatrilat''' is a drug which acts as an [[vasopeptidase]] [[enzyme inhibitor|inhibitor]].<ref name="pmid12472769">{{cite journal |author=Laver {{ACE inhibitors}}
  2 KB (256 words) - 09:44, 20 September 2010
• Renin inhibitor
  '''Renin inhibitor''', or inhibitors of [[renin]], are a new group of [[pharmaceutical]]s that are used primaril ...me="ref 1"> [http://pharmaxchange.info/presentations/dri.html Direct Renin Inhibitors Presentation]</ref>
  5 KB (697 words) - 09:44, 20 September 2010
• Thiomer
  ...xhibit mucoadhesive, permeation enhancing, controlled release as well as [[enzyme]] and [[efflux pump]] inhibitory properties. These features make the thiome ...chnürch A. In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials 2006;27(34):5855-60.
  4 KB (563 words) - 10:09, 20 September 2010
• Octopamine
  ...iomer]] of octopamine is by β-[[hydroxylation]] of [[tyramine]] via the [[enzyme]] [[dopamine β-hydroxylase]]. Under the trade names '''Epirenor''', '''Nor
  7 KB (980 words) - 13:14, 20 September 2010
• Nepicastat
  ...hibitor]] of [[Dopamine beta hydroxylase|dopamine beta-hydroxylase]], an [[enzyme]] that catalyzes the conversion of [[dopamine]] to [[norepinephrine]].<ref> {{Enzyme inhibition}}
  3 KB (335 words) - 13:15, 20 September 2010
• Needlestick injury
  ...d, follow-up of exposed individuals includes counseling and HIV testing by enzyme immunoassay to monitor for a possible seroconversion for at least 6 months
  17 KB (2,487 words) - 21:33, 20 September 2010
• Phenanthroline
  ...volume = 1 | pages = 231–238 | pmid = 13892106}}</ref> Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic act ...nd the oxidised form is light-blue. Ferroin is used as a cell permeable [[Enzyme inhibitor|inhibitor]] for [[metalloprotease]]s in cell biology.
  6 KB (660 words) - 20:14, 21 September 2010
• Ethylenediaminetetraacetic acid
  ...biology]], ion depletion is commonly used to deactivate metal-dependent [[enzyme]]s, either as an assay for their reactivity or to suppress damage to DNA or * The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/smi_summary?mid=J00149 EDTA]
  21 KB (3,011 words) - 16:51, 27 September 2010
• Hemoglobin
  ...iron will remain oxidized and incapable to bind oxygen. In such cases, the enzyme [[cytochrome b5 reductase|methemoglobin reductase]] will be able to eventua ...nner, hemoglobin ligands also include [[competitive inhibition|competitive inhibitors]] such as [[carbon monoxide]] (CO) and [[allosteric regulation|allosteric]]
  67 KB (9,844 words) - 20:17, 21 September 2010
• Angiotensin
  ...emoval of two C-terminal residues by the enzyme ''[[angiotensin-converting enzyme]]'' (ACE, or ''kinase''), which is found predominantly in the [[capillary|c * The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.953 I04.953]
  14 KB (1,818 words) - 21:27, 21 September 2010
• Renin-angiotensin system
  ...s [[macula densa]] decreases, then the juxtaglomerular cells release the [[enzyme]] [[renin]]. ...onverted to ''[[angiotensin|angiotensin II]]'' by [[angiotensin-converting enzyme]] (ACE)<ref>{{cite journal |author=Paul M, Poyan Mehr A, Kreutz R |title=Ph
  11 KB (1,520 words) - 12:30, 28 January 2012
• Cannabinoid
  ...xed-function oxidases, mainly [[CYP 2C9]]. Thus supplementing with CYP 2C9 inhibitors leads to extended intoxication. Cannabinoid production starts when an [[enzyme]] causes [[geranyl pyrophosphate]] and [[Olivetol|olivetolic acid]] to comb
  49 KB (6,487 words) - 22:06, 21 September 2010
• Propanoic acid
  ...erisation|isomerised]] to L-methylmalonyl-CoA. A [[vitamin B12]]-dependent enzyme catalyzes rearrangement of L-methylmalonyl-CoA to [[succinyl-CoA]], which i ...pionyl-CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Propanoate is metabolized oxidatively by glia, which suggests astrocytic
  10 KB (1,395 words) - 22:06, 21 September 2010

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)