|Systematic (IUPAC) name|
6-[3-(1-adamantyl)-4-methoxy-phenyl] naphthalene-2-carboxylic acid
|ATC code||D10AD03 (WHO)|
|Molar mass||412.52 g/mol[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene is marketed by Galderma under the trade names Differin in some countries, Adaferin in India, and Epiduo. Epiduo also contains benzoyl peroxide.
Adapalene is applied once daily, after washing and before retiring. In some circumstances, when a patient complains of skin irritation, the application may be decreased to once every other day until the irritation ceases. The prescribing doctor may also recommend washing the applied areas with soap and water a specified period after usage to reduce irritation.
In the United States, adapalene is available under the brand name Differin in three different preparations: 0.1% cream, 0.1% gel, and 0.3% gel. In Europe, only the 0.1% cream and 0.1% gel are available. In Pakistan, adapalene is available under the brand names Clear by Saffron Pharmaceuticals and Gallet by Pharma Health Pakistan, both of these are in the form of 0.1% cream. In India it it available under the trade name Adelene with 0.1 % Adapalene and 1 % Clindamycin phosphate.
Adapalene has been shown to enhance the efficacy of topical clindamycin, although adverse effects are also increased. Application of adapalene gel to the skin 3–5 minutes before application of clindamycin enhances penetration of clindamycin into the skin, which may enhance the overall efficacy of the treatment as compared to clindamycin alone.
Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects. The exact mode of action of adapalene is unknown.
Adapalene is applied topically to the skin, and its absorption into the blood through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.
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- Differin product insert
- Adapalene General Information, Patient Information, Contraindications and Interactions
- [www.epiduo.com/Includes/PDF/BriefSummary.pdf Epiduo Prescribing Information]
- Rolewski S (2003). "Clinical review: topical retinoids". Dermatol Nurs. 15 (5): 447–50, 459–65. PMID 14619325.
- (Patient Drug Information, uptodate.com, August 2009)
- About Differin
- Wolf JE, Kaplan D, Kraus SJ; et al. (2003). "Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study". J Am Acad Dermatol. 49 (3 Suppl): S211–7. doi:10.1067/S0190-9622(03)01152-6. PMID 12963897.
- Jain GK, Ahmed FJ (2007). "Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies". Indian J Dermatol Venereol Leprol. 73 (5): 326–9. doi:10.4103/0378-6323.34010. PMID 17921613.
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