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Systematic (IUPAC) name
Pharmacokinetic data
Biological half-life 7 to 12.8 hours
CAS Number 144-80-9
ATC code S01AB04 (WHO)
PubChem CID 5320
DrugBank APRD00452
Chemical data
Formula C8H10N2O3S
Molar mass 214.243 g/mol[[Script error: No such module "String".]]
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Sulfacetamide is a sulfonamide antibiotic.


Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis.[1] When combined with sulfur, it is sold under the brand name PLEXION and AVAR, which contain 10% sulfacetamide and 5% sulfur.

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor[2] and rosacea.[3] It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis.[citation needed] It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa.[citation needed] Sulfacetamide has antibacterial activity and is used to control acne. Products containing sulfacetamide and sulfur (a keratolytic) are commonly promoted for the treatment of acne rosacea (rosacea with papules, pustules, or both). There are several prescription topical products containing sulfacetamide, such as foams, shampoos, cream and washes.

Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism.[4]

Adverse effects

The most common side effects of sulfacetamide/sulfur combination products are local irritation and contact dermatitis. Sulfacetamide should not be used by individuals who have a sensitivity to sulfur or sulfa.


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  4. Mastrolorenzo A, Supuran CT (2000). "Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives". Met Based Drugs. 7 (1): 49–54. doi:10.1155/MBD.2000.49. PMC 2365193Freely accessible. PMID 18475922.