BAY 60–6583
From Self-sufficiency
| BAY 60–6583 | |
|---|---|
| File:BAY60-6583 structure.png | |
| 2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-ylsulfanyl]acetamide | |
| Other names BAY 60–6583 | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 910487-58-0 |
| PubChem | 11717831 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C19H17N5O2S |
| Molar mass | 379.435 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
BAY 60–6583 is a selective adenosine A2B receptor agonist.[1] It has been shown to provide protection from ischemia (lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals,[2][3] and has also been shown to be beneficial in treatment of acute lung injury,[4] showing a range of potential applications for selective A2B agonists.
 |
This pharmacology-related article is a stub. You can help ssf by expanding it. |
References
Cite error: Invalid <references> tag;
parameter "group" is allowed only.
<references />, or <references group="..." />- ↑ Baraldi PG, Tabrizi MA, Fruttarolo F, Romagnoli R, Preti D. Recent improvements in the development of A(2B) adenosine receptor agonists. Purinergic Signalling. 2008 Dec;4(4):287-303. PMID 18443746
- ↑ Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27;115(12):1581-90. PMID 17353435
- ↑ Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Medicine. 2008 Jun 24;5(6):e137. PMID 18578565
- ↑ Eckle T, Grenz A, Laucher S, Eltzschig HK. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. Journal of Clinical Investigation. 2008 Oct;118(10):3301-15. PMID 18787641
