PSB-10

From Self-sufficiency
Jump to: navigation, search
PSB-10
240px
Systematic (IUPAC) name
(8R)-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one
Identifiers
Synonyms PSB-10
Chemical data
Formula C16H16Cl3N5O
Molar mass 400.690 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

PSB-10 is a drug which acts as a selective inverse agonist[1] for the adenosine A3 receptor, with high selectivity over the other three adenosine receptor subtypes. It has been shown to produce antiinflammatory effects in animal studies.[2] Simple xanthine derivatives such as caffeine and DPCPX have generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity.[3]

Stub icon This pharmacology-related article is a stub. You can help ssf by expanding it.

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


Receptor ligands
Reuptake inhibitors
ENT inhibitors
VNT inhibitors
 
  1. ↑ Hallmen C, Wiese M (2006). "Molecular dynamics simulation of the human adenosine A3 receptor: agonist induced conformational changes of Trp243". Journal of Computer-aided Molecular Design. 20 (10-11): 673–84. doi:10.1007/s10822-006-9088-5. PMID 17124628. 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ Müller CE (2003). "Medicinal chemistry of adenosine A3 receptor ligands". Current Topics in Medicinal Chemistry. 3 (4): 445–62. doi:10.2174/1568026033392174. PMID 12570761. 
Retrieved from "http://ssf.f15ijp.com/wiki/index.php?title=PSB-10&oldid=32475"