Istradefylline

Istradefylline
	File:Istradefylline.svg
Systematic (IUPAC) name
	8-[(E)-2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
Identifiers
CAS Number	155270-99-8
ATC code	none
PubChem	CID 5311037
Chemical data
Formula	C20H24N4O4
Molar mass	384.429 g/mol[[Script error: No such module "String".]]
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Istradefylline (KW-6002) is an antagonist at the A_2A receptor. It has been found to be useful in the treatment of Parkinson's disease.^[1] Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa.

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References

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↑ Peter A. LeWitt, MD, M. Guttman, James W. Tetrud, MD, Paul J. Tuite, MD, Akihisa Mori, PhD, Philip Chaikin, PharmD, MD, Neil M. Sussman, MD (2008). "Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces off time in Parkinson's disease: A double-blind, randomized, multicenter clinical trial (6002-US-005)". Annals of Neurology. 63 (3): 295–302. doi:10.1002/ana.21315. PMID 18306243.