Besifloxacin
| File:Besifloxacin.png | |
| Systematic (IUPAC) name | |
|---|---|
|
7-[(3R) -3-aminoazepam- 1-yl]- 8-chloro- 1-cyclopropyl- 6-fluoro- 4-oxo- 1,4- dihydroquinoline- 3-carboxylic acid | |
| Clinical data | |
| [[Regulation of therapeutic goods |Template:Engvar data]] |
|
| Routes of administration | Opthalmic |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 141388-76-3 |
| ATC code | none |
| Chemical data | |
| Formula | C19H21ClFN3O3 |
| Molar mass | Script error: No such module "math". g·mol−1 |
Besifloxacin (INN/USAN) is a fourth-generation fluoroquinolone antibiotic. The marketed compound is besifloxacin hydrochloride. It was developed by SSP Co. Ltd., Japan, and designated SS734. SSP licensed U.S. and European rights to SS734 for ophthalmic use to InSite Vision, Inc., in 2000. InSite Vision developed an eye drop formulation (ISV-403) and conducted preliminary clinical trials before selling the product and all rights to Bausch & Lomb in 2003.[1]
The eye drop was approved by the United States Food and Drug Administration (FDA) on May 29, 2009 and marketed under the trade name Besivance.[2]
Besifloxacin has been found to inhibit production of pro-inflammatory cytokines in vitro.[3]
See also
References
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- ↑ "InSite Vision Reaches Agreement to Sell ISV-403 to Bausch & Lomb" (Press release). InSite Vision. 2003-12-19. http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/12-19-2003/0002079091&EDATE=. Retrieved 2009-08-15.
- ↑ "Bausch & Lomb Receives FDA Approval of Besivance, New Topical Ophthalmic Antibacterial for the Treatment of Bacterial Conjunctivitis (“Pink Eye”)" (Press release). Bausch & Lomb. 2009-05-29. http://www.bausch.com/en_US/corporate/corpcomm/news/besivance_approval.aspx. Retrieved 2009-05-29.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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