Canagliflozin

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Canagliflozin
File:Canagliflozin.png
Systematic (IUPAC) name
(2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
Identifiers
CAS Number 842133-18-0
ATC code none
Synonyms JNJ-24831754; TA 7284; (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
Chemical data
Formula C24H25FO5S
Molar mass 444.52 g/mol[[Script error: No such module "String".]]
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Canagliflozin is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes.[1] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.[2]

References

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  1. Canagliflozin announcement of SGLT-2
  2. Prous Science: Molecule of the Month November 2007