Sergliflozin etabonate
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File:Sergliflozin etabonate.svg | |
Systematic (IUPAC) name | |
---|---|
2-(4-methoxybenzyl)phenyl 6-O-(ethoxycarbonyl)-β-D-glucopyranoside | |
Clinical data | |
Routes of administration | Oral |
Identifiers | |
CAS Number | 408504-26-7 |
ATC code | none |
PubChem | CID 9824918 |
Chemical data | |
Formula | C23H28O9 |
Molar mass | 448.463 g/mol[[Script error: No such module "String".]] |
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Sergliflozin etabonate (INN/USAN,[1][2] codenamed GW869682X) is an investigational anti-diabetic drug being developed by GlaxoSmithKline. It did not undergo further development after phase II.[citation needed]
Method of action
Sergliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.[3][4]
References
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- ↑ World Health Organization (2008). "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 59" (PDF). WHO Drug Information. 22 (1): 66.
- ↑ "Statement on a nonproprietary name adopted by the USAN council: Sergliflozin etabonate" (PDF). American Medical Association. Retrieved 2008-08-10.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Prous Science: Molecule of the Month November 2007
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