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Systematic (IUPAC) name
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
  • US: B (No risk in non-human studies)
Routes of
Oral, IM
Pharmacokinetic data
Bioavailability 37 to 90%
Protein binding 95%
Biological half-life 30 minutes to 1 hour
Excretion Renal and biliary
CAS Number 61-72-3
ATC code J01CF02 (WHO) QJ51CF02 QS01AA90
PubChem CID 6098
DrugBank APRD00882
ChemSpider 5873
Chemical data
Formula C19H18ClN3O5S
Molar mass 435.88 g/mol[[Script error: No such module "String".]]
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Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin was discovered and developed by Beecham. It is sold under a number of trade names, including Cloxapen, Cloxacap and Orbenin.

Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain which doesn't allow the beta-lactamases to bind.

This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.

It has been suggested, in one study, that increased use of cloxacillin may permit reduced use of vancomycin.[1]

See also


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es:Cloxacilina fa:کلوگزاسیلین fr:Cloxacilline it:Cloxacillina hu:Kloxacillin pl:Kloksacylina

  1. Lawrence SL, Roth V, Slinger R, Toye B, Gaboury I, Lemyre B (2005). "Cloxacillin versus vancomycin for presumed late-onset sepsis in the Neonatal Intensive Care Unit and the impact upon outcome of coagulase negative staphylococcal bacteremia: a retrospective cohort study". BMC Pediatr. 5: 49. doi:10.1186/1471-2431-5-49. PMC 1343548Freely accessible. PMID 16375769.