Nafcillin

From Self-sufficiency
Jump to: navigation, search
Nafcillin
File:Nafcillin.svg
Systematic (IUPAC) name
(2S,5R,6R)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
administration
IM, IV
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Protein binding 90%
Metabolism <30% hepatic
Biological half-life 0.5 hours
Excretion Biliary and renal
Identifiers
CAS Number 985-16-0
ATC code none
PubChem CID 8982
DrugBank APRD01130
Chemical data
Formula C21H22N2O5S
Molar mass 414.476 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
  (verify)
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Nafcillin sodium is a narrow-spectrum[1] beta-lactam antibiotic[2] of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, in particular, species of staphylococci that are resistant to other penicillins.

Nafcillin is considered therapeutically equivalent to oxacillin, although its safety profile is somewhat different.[3]

Indications

Nafcillin is indicated in the treatment of staphylococcal infections, except those caused by MRSA.[3]

U.S. clinical practice guidelines recommend either nafcillin or oxacillin as the first-line treatment of choice for staphylococcal endocarditis in patients without artificial heart valves.[4]

Side-effects

As with all penicillins, serious life-threatening allergic reactions can occur.

Milder side-effects include:

Interactions

There is evidence that it induces cytochrome P-450 enzymes.[5]

The other aspect of this medication is that this medication contains lots of salts as media. So it could cause some edema or fluid accumulation. It would be prudent to avoid this medication if there were a concern for a congestive heart failure or kidney disease.

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />
fa:نافسیلین it:Nafcillina
  1. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. 3.0 3.1 Pham P, Bartlett JG (January 2, 2009). "Nafcillin". Point-of-Care Information Technology ABX Guide. Johns Hopkins University.  Retrieved on July 10, 2009. Freely available with registration.
  4. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  5. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.