Phenoxymethylpenicillin

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Phenoxymethylpenicillin
File:Penicillin-V-2D-skeletal.png
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-7-oxo-6- [(phenylacetyl)amino]- 4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid
Clinical data
[[Regulation of therapeutic goods |Template:Engvar data]]
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
administration
enteral
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 60%
Protein binding 80%
Metabolism hepatic
Biological half-life 30–60 min
Excretion renal
Identifiers
CAS Number 87-08-01 , 132-98-9 (potassium), 147-48-8 (anhydrous calcium), 73368-74-8 (calcium dihydrate)
ATC code J01CE02
PubChem CID 6869
DrugBank DB00417
Chemical data
Formula C16H18N2O5S
Molar mass 350.39 g/mol[[Script error: No such module "String".]]
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Phenoxymethylpenicillin, commonly known as penicillin V, is the orally active form of penicillin, an antibiotic. It is less active than benzylpenicillin, however, and is appropriate only in conditions where high tissue concentrations are not required. Phenoxymethylpenicillin exerts a bactericidal action against penicillin sensitive microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall Peptidoglycan. It is not active against the Beta-lactamase-producing bacteria, which include many strains of staphylococci.[1]

Phenoxymethylpenicillin has a range of antimicrobial activity similar to that of benzylpenicillin and a similar mode of action. It may be less active against some susceptible organisms, particularly Gram-negative bacteria. The mechanisms and patterns of resistance to phenoxymethylpenicillin are similar to those of benzylpenicillin.[1][2]

It is used only for the treatment of mild to moderate infections, and not for chronic, severe, or deep-seated infections since absorption can be unpredictable. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[1] Patients treated initially with parenteral benzylpenicillin may continue oral treatment with phenoxymethylpenicillin once a satisfactory clinical response has been obtained.[2]

Indications

Specific indications for phenoxymethylpenicillin include:[2][3]

Penicillin V is the first choice in the treatment of odontogenic infections.

Adverse Effects and Precautions

Phenoxymethylpenicillin is usually well tolerated but may occasionally cause transient nausea, vomiting, epigastric distress, diarrhea, and black hairy tongue. A previous hypersensitivity reaction to any penicillin is a contraindication.[1][2]

Toxicology

Compendial status

References

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See also

da:Phenoxymethylpenicillin

es:Fenoximetilpenicilina fr:PénicillineV hr:Fenoksimetilpenicilin it:Fenossimetilpenicillina pl:Fenoksymetylopenicylina sl:Fenoksimetilpenicilin sv:Fenoximetylpenicillin

zh:青霉素V钾
  1. 1.0 1.1 1.2 1.3 "Penicillin V Potassium tablet: Drug Label Sections". U.S. National Library of Medicine, Daily Med: Current Medication Information. 12/2006. Retrieved 2009-08-02.  Check date values in: |date= (help)
  2. 2.0 2.1 2.2 2.3 Sweetman S., ed. (2002). Martindale: The complete drug reference (Electronic version ed.). London: Royal Pharmaceutical Society of Great Britain and the Pharmaceutical Press. 
  3. Rossi S., ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pty Ltd. ISBN 0-9757919-2-3. 
  4. British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Retrieved 26 March 2010.