Frank's sign

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File:Gray904.png
Normal Ear Anatomy

Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle.[1]

It has been hypothesised that Frank's sign is a sign of cardiovascular disease[2] and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition.[3] In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease.[4]

Some studies have focused upon bilateral ELC.[5]

The sign is named after Dr. Sanders T. Frank.[citation needed]

Severity

External links

Notable Individuals with Frank's Sign

Links to images

References

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  2. Miot, H.A., Molina de Medeiros, M. etal (2006). Association between coronary artery disease and the diagonal earlobe an preauricular creases in men. Anais Brasileiros de Dermatologia. vol.81 no.1
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  5. Evrengül H, Dursunoğlu D, Kaftan A; et al. (2004). "Bilateral diagonal earlobe crease and coronary artery disease: a significant association". Dermatology (Basel). 209 (4): 271–5. doi:10.1159/000080847. PMID 15539887.