Vorozole
From Self-sufficiency
| File:Vorozole.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
6-[(4-chlorophenyl)-(1,2,4-triazol-1-yl)methyl]- 1-methyl-benzotriazole | |
| Pharmacokinetic data | |
| Bioavailability | Very high |
| Metabolism | Hepatic |
| Biological half-life | 8 hours |
| Identifiers | |
| CAS Number | 118949-22-7 |
| ATC code | L02BG05 (WHO) |
| PubChem | CID 60796 |
| Chemical data | |
| Formula | C16H13ClN6 |
| Molar mass | 324.768 g/mol[[Script error: No such module "String".]] |
Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.
It is selective.[1]
Chemistry
Prous, J.; Grant, J.; Castaner, J.; Drugs Future 1994, 457.
References
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| 40px | This antineoplastic or immunomodulatory drug article is a stub. You can help ssf by expanding it. |
- ↑ Goss PE (1998). "Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor" (PDF). Breast Cancer Res. Treat. 49 Suppl 1: S59–65; discussion S73–7. PMID 9797019.
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