Difference between revisions of "Rolofylline"
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Latest revision as of 15:46, 19 September 2010
| File:Rolofylline2.png | |
| Systematic (IUPAC) name | |
|---|---|
|
8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 136199-02-5 |
| ATC code | C03BD (WHO) |
| PubChem | CID 64627 |
| ChemSpider | 58188 |
| Chemical data | |
| Formula | C20H28N4O2 |
| Molar mass | 356.46 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Rolofylline (KW-3902) is an experimental diuretic which acts as a selective adenosine A1 receptor antagonist.[1][2] It was discovered at NovaCardia, Inc. which was purchased by Merck & Co., Inc. in 2007.
Development of rolofylline was terminated on September 1, 2009, after the results of a large clinical trial (PROTECT) showed the drug to be no better than placebo for patients with acute heart failure. Participants given rolofylline did show some improvement in shortness of breath, but the drug did not prevent kidney damage or have any significant effect on overall treatment success. Rolofylline was also associated with a higher incidence of seizures and stroke.[3]
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Hughes, Sue (September 1, 2009). "Rolofylline fails to PROTECT in acute heart failure". Medscape. Retrieved 2009-09-02.
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