Difference between revisions of "Cloxacillin"
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Latest revision as of 10:25, 20 September 2010
| File:Cloxacillin.svg | |
| Systematic (IUPAC) name | |
|---|---|
|
(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl- oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | |
| Clinical data | |
| Pregnancy category |
|
| Routes of administration | Oral, IM |
| Pharmacokinetic data | |
| Bioavailability | 37 to 90% |
| Protein binding | 95% |
| Biological half-life | 30 minutes to 1 hour |
| Excretion | Renal and biliary |
| Identifiers | |
| CAS Number | 61-72-3 |
| ATC code | J01CF02 (WHO) QJ51CF02 QS01AA90 |
| PubChem | CID 6098 |
| DrugBank | APRD00882 |
| ChemSpider | 5873 |
| Chemical data | |
| Formula | C19H18ClN3O5S |
| Molar mass | 435.88 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
| (verify) | |
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin was discovered and developed by Beecham. It is sold under a number of trade names, including Cloxapen, Cloxacap and Orbenin.
Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain which doesn't allow the beta-lactamases to bind.
This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.
It has been suggested, in one study, that increased use of cloxacillin may permit reduced use of vancomycin.[1]
See also
References
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es:Cloxacilina fa:کلوگزاسیلین fr:Cloxacilline it:Cloxacillina hu:Kloxacillin pl:Kloksacylina
th:คลอกซาซิลลิน- ↑ Lawrence SL, Roth V, Slinger R, Toye B, Gaboury I, Lemyre B (2005). "Cloxacillin versus vancomycin for presumed late-onset sepsis in the Neonatal Intensive Care Unit and the impact upon outcome of coagulase negative staphylococcal bacteremia: a retrospective cohort study". BMC Pediatr. 5: 49. doi:10.1186/1471-2431-5-49. PMC 1343548 Freely accessible. PMID 16375769.
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- Antibiotic stubs
- Beta-lactam antibiotics
- World Health Organization essential medicines
- Isoxazoles
- Organochlorides
- 2Fix
- CS1 maint: Multiple names: authors list
