Difference between revisions of "Vorozole"

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Vorozole
File:Vorozole.svg
Systematic (IUPAC) name
6-[(4-chlorophenyl)-(1,2,4-triazol-1-yl)methyl]-
1-methyl-benzotriazole
Pharmacokinetic data
Bioavailability Very high
Metabolism Hepatic
Biological half-life 8 hours
Identifiers
CAS Number 118949-22-7
ATC code L02BG05 (WHO)
PubChem CID 60796
Chemical data
Formula C16H13ClN6
Molar mass 324.768 g/mol[[Script error: No such module "String".]]
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Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.

It is selective.[1]

Chemistry

File:Vorozole synth.svg

Prous, J.; Grant, J.; Castaner, J.; Drugs Future 1994, 457.

References

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Estrogens and progestogens (G03C-D, L02)
Progestogens/
progestins
(progesterone)
Agonist
Other/
ungrouped
Estrogens
Agonist


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  1. ↑ Goss PE (1998). "Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor" (PDF). Breast Cancer Res. Treat. 49 Suppl 1: S59–65; discussion S73–7. PMID 9797019. 
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