Taltirelin
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| File:Talitirelin.png | |
| Systematic (IUPAC) name | |
|---|---|
|
N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide | |
| Clinical data | |
| Routes of administration | Oral |
| Identifiers | |
| CAS Number |
103300-74-9 201677-75-0 |
| ATC code | none |
| PubChem | CID 656609 |
| Synonyms | (4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide |
| Chemical data | |
| Formula | C17H31N7O9 |
| Molar mass | 477.46 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects,[1] and little development of tolerance following prolonged dosing.[2] It has nootropic,[3] neuroprotective[4] and analgesic effects,[5] and is primarily being researched for the treatment of Spinocerebellar ataxia.
References
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<references />, or <references group="..." />- (Japanese) Ceredist セレジスト錠 (PDF) Mitsubishi Tanabe Pharma. October 2007.
External links
- (Japanese) Official Mitsubishi Tanabe Pharma Website
| 35px | This drug article relating to the nervous system is a stub. You can help ssf by expanding it. |
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Asai H, Asahi T, Yamamura M, Yamauchi-Kohno R, Saito A. Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacology, Biochemistry and Behaviour. 2005 Dec;82(4):646-51. PMID 16368129
- ↑ Yamamura M, Suzuki M, Matsumoto K. Synthesis and pharmacological action of TRH analog peptide (Taltirelin). Nippon Yakurigaku Zasshi. (Japanese). 1997 Oct;110 Suppl 1:33P-38P. PMID 9503402
- ↑ Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sciences. 2002 Dec 20;72(4-5):601-7. PMID 12467901
- ↑ Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H. The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. British Journal of Pharmacology. 2007 Feb;150(4):403-14. PMID 17220907
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