PEPA (drug)

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For the process algebra, see PEPA
PEPA (drug)
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Systematic (IUPAC) name
2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}thio)phenoxy]acetamide
Legal status
Legal status
  • Investigational New Medicine
Identifiers
CAS Number 141286-78-4
PubChem CID 6603828
Synonyms PEPA
Chemical data
Formula C16H16F2N2O4S2
Molar mass 402.436 g/mol[[Script error: No such module "String".]]
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PEPA is an ampakine drug which acts as an allosteric potentiator of AMPA receptor desensitisation,[1][2] which is up to 100x more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]



References

  1. ↑ Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. British Journal of Pharmacology. 1998 Apr;123(7):1294-303. PMID 9579722
  2. ↑ Sekiguchi M, Nishikawa K, Aoki S, Wada K. A desensitization-selective potentiator of AMPA-type glutamate receptors. British Journal of Pharmacology. 2002 Aug;136(7):1033-41. PMID 12145103
  3. ↑ Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K. A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide. Journal of Neuroscience. 1997 Aug 1;17(15):5760-71. PMID 9221774
  4. ↑ Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, Kamichi S, Kimura I, Wada K. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport. 2001 Sep 17;12(13):2947-50. PMID 11588608


Psychostimulants, agents used for ADHD, and nootropics (N06B)
Centrally acting sympathomimetics
Xanthine derivatives
Glutamate receptor
CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-404,187 • LY-503,430 • PEPA • S-18986 • Sunifiram • Unifiram
Eugeroics / Benzhydryl compounds
Histamine H3 receptor antagonists
GABAA α5 inverse agonists
Dopamine D1 receptor agonists
α7 nicotinic agonists / PAMs
Prolyl endopeptidase inhibitors
Other psychostimulants and nootropics

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc, drug(N5A/5B/5C/6A/6B/6D)


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