PWZ-029
From Self-sufficiency
| File:PWZ-029 structure.png | |
| Systematic (IUPAC) name | |
|---|---|
|
8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one | |
| Identifiers | |
| PubChem | CID 9971547 |
| Chemical data | |
| Formula | C14H14ClN3O2 |
| Molar mass | 291.732 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
PWZ-029 is a benzodiazepine derivative drug with nootropic effects. It acts as a subtype-selective, mixed agonist-inverse agonist at the benzodiazepine binding site on the GABAA receptor, acting as a partial inverse agonist at the α5 subtype and a weak partial agonist at the α3 subtype. This gives it a mixed pharmacological profile, producing at low doses memory-enhancing effects but with no convulsant or anxiogenic effects or muscle weakness, although at higher doses it produces some sedative effects.[1]
See also
References
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- ↑ Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 2008 May 7;1208:150-9. PMID 18394590
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