Sunifiram
From Self-sufficiency
240px | |
Systematic (IUPAC) name | |
---|---|
1-benzoyl-4-propanoylpiperazine | |
Identifiers | |
CAS Number | 314728-85-3 |
PubChem | CID 4223812 |
Chemical data | |
Formula | C14H18N2O2 |
Molar mass | 246.304 g/mol[[Script error: No such module "String".]] |
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Sunifiram (DM-235) is an ampakine drug which acts as a positive allosteric modulator of AMPA receptors,[1] and has nootropic effects in animal studies with significantly higher potency than piracetam.[2][3] A number of related compounds are known, the best known being unifiram (DM-232).[4][5][6]
References
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- ↑ Galeotti, N.; Ghelardini, C.; Pittaluga, A.; Pugliese, A.; Bartolini, A.; Manetti, D.; Romanelli, M.; Gualtieri, F. (2003). "AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)". Naunyn-Schmiedeberg's archives of pharmacology. 368 (6): 538–545. doi:10.1007/s00210-003-0812-6. PMID 14600801.
- ↑ Ghelardini, C.; Galeotti, N.; Gualtieri, F.; Romanelli, M.; Bucherelli, C.; Baldi, E.; Bartolini, A. (2002). "DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer". Naunyn-Schmiedeberg's archives of pharmacology. 365 (6): 419–426. doi:10.1007/s00210-002-0577-3. PMID 12070754.
- ↑ Romanelli, M.; Galeotti, N.; Ghelardini, C.; Manetti, D.; Martini, E.; Gualtieri, F. (2006). "Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers". CNS drug reviews. 12 (1): 39–52. doi:10.1111/j.1527-3458.2006.00039.x. PMID 16834757.
- ↑ Scapecchi, S; Martini, E; Manetti, D; Ghelardini, C; Martelli, C; Dei, S; Galeotti, N; Guandalini, L; Novella Romanelli, M (2004). "Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs". Bioorganic & medicinal chemistry. 12 (1): 71–85. doi:10.1016/j.bmc.2003.10.025. PMID 14697772.
- ↑ Martini, E.; Ghelardini, C.; Dei, S.; Guandalini, L.; Manetti, D.; Melchiorre, M.; Norcini, M.; Scapecchi, S.; Teodori, E. (2008). "Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers". Bioorganic & medicinal chemistry. 16 (3): 1431–1443. doi:10.1016/j.bmc.2007.10.050. PMID 17981042.
- ↑ Martini, E.; Norcini, M.; Ghelardini, C.; Manetti, D.; Dei, S.; Guandalini, L.; Melchiorre, M.; Pagella, S.; Scapecchi, S. (2008). "Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators". Bioorganic & medicinal chemistry. 16 (23): 10034–10042. doi:10.1016/j.bmc.2008.10.017. PMID 18954993. More than one of
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