Cefoperazone

Cefoperazone

File:Cefoperazone.svg
Systematic (IUPAC) name
(6R,7S)-7-{[2-[(4-ethyl-2,3-dioxo-piperazine-1- carbonyl)amino]-2-(4-hydroxyphenyl)acetyl}amino]- 3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Pharmacokinetic data
Excretion	Hepatic
Identifiers
CAS Number	62893-19-0
ATC code	J01DD12 (WHO) QJ51DA32
PubChem	CID 44185
ChemSpider	40206
Chemical data
Formula	C25H27N9O8S2
Molar mass	645.67 g/mol[[]]
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Cefoperazone is a third generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid, and also marked by pharco B international under the name of Cefazone. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.

Cefina-SB is a combination of sulbactam and cefoperazone. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase producing organisms. In some countries, the combination is sold as Sulperazone. Gepach International markets this combination of Cefoperazone with Sulbactam under the brand name Bacperazone

Adverse effects

Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.

References

es:Cefoperazona pl:Cefoperazon