Alclometasone

From Self-sufficiency
Jump to: navigation, search
Alclometasone
File:Alclometasone.png
Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
Routes of
administration
topical
Legal status
Legal status
  • Rx Only (US)
Identifiers
CAS Number 66734-13-2
ATC code D07AB10 (WHO) S01BA10
PubChem CID 5311000
DrugBank APRD00783
ChemSpider 4470541
Chemical data
Formula C28H37ClO7
Molar mass 521.042 g/mol[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

Side effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

  • burning
  • itching
  • erythema
  • skin reddening
  • xerodermia
  • skin irritation
  • acne
  • hypopigmentation
  • prickly heat
  • folliculitis
  • white atrophy
  • hypertrichosis
  • reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%

External links

ja:アルクロメタゾン