Loteprednol

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Loteprednol
File:Loteprednol etabonate.svg
Systematic (IUPAC) name
chloromethyl 17-ethoxycarbonyloxy- 11-hydroxy- 10,13-dimethyl-3-oxo- 7,8,9,11,12,14,15, 16-octahydro- 6H-cyclopenta[a] phenanthrene-17-carboxylate
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Legal status
Legal status
Identifiers
CAS Number 82034-46-6
ATC code S01BA14 (WHO)
PubChem CID 444025
DrugBank APRD01078
Chemical data
Formula C24H31ClO7
Molar mass 466.951 g/mol[[Script error: No such module "String".]]
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Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used in ophthalmology. Marketed by Bausch and Lomb as Lotemax in the U.S., ocular applications for this drug include the treatment of inflammation of the eye due to allergies (according to the prescription information sheet), as well as chronic forms of keratitis (e.g.: adenoviral and Thygeson’s keratitis), vernal keratoconjunctivitis, pingueculitis, and episcleritis. The drug has little or no effect on intraocular pressure.

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Druzgala, P.; Hochhaus, G.; Bodor, N.; J. Steroid Biochem. Mol. Biol. 1991, 38, 149.

http://dx.doi.org/10.1016/0960-0760(91)90120-T

References

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  • Pavesio, CE; Decory, HH (2008). "Treatment of ocular inflammatory conditions with loteprednol etabonate". Br J Ophthalmol. 92 (4): 455–459. doi:10.1136/bjo.2007.132621. PMID 18245274. 


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