Mometasone furoate
File:Mometasone furoate.png | |
Systematic (IUPAC) name | |
---|---|
(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
Clinical data | |
Pregnancy category |
|
Routes of administration | topical, nasal |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
Protein binding | 98% to 99% |
Metabolism | hepatic |
Biological half-life | 5.8 hours |
Identifiers | |
CAS Number | 105102-22-5 83919-23-7 as Furoate |
ATC code | D07AC13 (WHO) D07XC03, R01AD09, R03BA07 |
PubChem | CID 123620 |
DrugBank | APRD00289 |
Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
Chemical data | |
Formula |
C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
Molar mass |
427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
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Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.
Contents
[hide]Uses, administration, and pharmacodynamics
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis [4]. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[citation needed]
It reduces inflammation by causing several effects:[5][6]
- reversing the activation of inflammatory genes
- activating the secretion of anti-inflammatory proteins
- stabilising cell membranes
- decreasing the influx of inflammatory cells
Availability
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[7]
References
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External links
- Mometasone Furoate Oral Inhalation (MedlinePlus)
- Mometasone Furoate Nasal Inhalation (MedlinePlus)
- Nasonex Home page
- Asmanex Home page
- U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate
nl:Mometasonfuroaat pl:Mometazon pt:Mometasona
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- Jump up ↑ Publishers, Jones and Bartlett (2009-07-15). "Nurse's Drug Handbook 2010". p. 677. ISBN 9780763779009.
- Jump up ↑ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 9781932610383.
- Jump up ↑ "Mometamax". Intervet USA. Retrieved 19 June 2010.
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- 2Fix
- Glucocorticoids
- Asthma
- Schering-Plough
- Furoates
- Organochlorides