Mometasone furoate
File:Mometasone furoate.png | |
Systematic (IUPAC) name | |
---|---|
(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
Clinical data | |
Pregnancy category |
|
Routes of administration | topical, nasal |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
Protein binding | 98% to 99% |
Metabolism | hepatic |
Biological half-life | 5.8 hours |
Identifiers | |
CAS Number | 105102-22-5 83919-23-7 as Furoate |
ATC code | D07AC13 (WHO) D07XC03, R01AD09, R03BA07 |
PubChem | CID 123620 |
DrugBank | APRD00289 |
Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
Chemical data | |
Formula |
C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
Molar mass |
427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
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Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.
Uses, administration, and pharmacodynamics
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis [4]. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[citation needed]
It reduces inflammation by causing several effects:[5][6]
- reversing the activation of inflammatory genes
- activating the secretion of anti-inflammatory proteins
- stabilising cell membranes
- decreasing the influx of inflammatory cells
Availability
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[7]
References
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External links
- Mometasone Furoate Oral Inhalation (MedlinePlus)
- Mometasone Furoate Nasal Inhalation (MedlinePlus)
- Nasonex Home page
- Asmanex Home page
- U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate
nl:Mometasonfuroaat pl:Mometazon pt:Mometasona
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- ↑ Publishers, Jones and Bartlett (2009-07-15). "Nurse's Drug Handbook 2010". p. 677. ISBN 9780763779009.
- ↑ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 9781932610383.
- ↑ "Mometamax". Intervet USA. Retrieved 19 June 2010.
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- 2Fix
- Glucocorticoids
- Asthma
- Schering-Plough
- Furoates
- Organochlorides